Assessment of Lipophilic vs hydrophilic statin therapy in acute myocardial infarction. Izawa A,Kashima Y,Miura T,et al. Circulation Journal . 2014Assessment of lipophilic vs.hydrophilic statin therapy in acute myocardial infarction-ALPS-AMI study. IZAWA A,KASHIMA Y,MIURA T,et al. Circulation ...
Aims There are insufficient direct comparative studies addressing the impact of the type of statin on their respective efficacy in heart failure (HF). The aim of the current study was to compare the effects of lipophilic (atorvastatin) vs hydrophilic (rosuvastatin) on left ventricular function, ...
This is the first multicenter trial to compare the effects and safety of lipophilic and hydrophilic statin therapy in Japanese patients with AMI. It addresses an important issue and could influence the use of statin treatment in the secondary prevention of coronary artery disease....
The measures of interest were hearing loss risk between hydrophilic and lipophilic statin use. Variables were compared using propensity score matching, Cox proportional regression, and meta-analysis. Among 37,322 patients with hyperlipidemia, 13,751 (7669 men and 6082 women) and 23,631 (11,390 ...
Lipophilic statin versus hydrophilic statin treatment on cardiac function and inflammation in heart failure: A systematic review and an adjusted indirect comparison meta-analysisNo abstract available.doi:10.1016/j.hlc.2015.06.237Osei Bonsu, K.
We evaluated the effect of atorvastatin, a lipophilic statin, and rosuvastatin, a hydrophilic statin, on muscle sympathetic nerve activity (MSNA) in HFpEF patients. This study was conducted as a prospective, randomized, open-label, crossover trial. Ten HFpEF patients with untreated hyperlipidemia ...
Patients New statin users. Cohort 1: pravastatin 20-40 mg (hydrophilic) vs simvastatin 10-20 mg (lipophilic), cohort 2: rosuvastatin 5-40 mg (hydrophilic) vs atorvastatin 10-80 mg (lipophilic), and cohort 3: simvastatin 40-80 mg vs atorvastatin 10-20 mg. Main Measures The outcome was ...
Hydrophilic vs. Lipophilic Statin Treatments in Patients with CKD After Acute Myocardial Infarction: A Propensity Score-Matched Comparisondoi:10.1681/ASN.20213210S1727dJongho KimSoo-Young YoonDae Kyu KimShinyeong KangJin sug KimKyung hwan Jeong...
Lipophilic Statin Versus Rosuvastatin (Hydrophilic) Treatment for Heart Failure: a Meta-Analysis and Adjusted Indirect Comparison of Randomised Trials. Cardiovasc Drugs Ther. 2016; 30 (2): 177-88. DOI: 10.1007/s10557- 015-6636-z.Lipophilic Statin Versus Rosuvastatin (Hydrophilic)Treatment for Heart...
The VACC currents were inhibited by the lipophilic statin (simvastatin) but not by the hydrophilic simvastatin acid and pravastatin. A low-molecular-weight superoxide anion scavenger (tiron, 1 mM) and inhibitor of NADPH oxidase (DPI 10 μM) was able to abolish the VACC currents. A ...