Therefore, we performed a meta-analysis of randomized controlled trials (RCTs) investigating the potential differences of lipophilic and hydrophilic statins in patients with CAD.MethodsWe systematically searched selected electronic databases up to September 2016 to select RCTs, which compared clinical ...
We investigated effects of chemically different statins on RhoA kinase inhibition in cardiac myocytes (CM). Neonatal mouse CM were treated with simvastatin, pitavastatin, atorvastatin, rosuvastatin, or pravastatin and compared to vehicle. After 48hs only lipophilic and not hydrophilic statins, induced ...
Background: Statins reduce the incidence of cardiovascular events, but no randomized trial has investigated the best statins for secondary prevention. We compared the efficacy of hydrophilic pravastatin with that of lipophilic atorvastatin in patients with acute myocardial infarction (AMI).Izawa, Atsushi...
Hydrophilic statinsINTRODUCTION: Some available experimental studies have reported that hydrophilic statins might have advantages compared with lipophilic statins in patients with coronary artery disease (CAD). Therefore, we performed a meta-analysis of randomized controlled trials (RCTs) investigating the ...
Lipophilic vs. hydrophilic statins and psychiatric hospitalizations and emergency room visits in US Veterans with schizophrenia and bipolar disorderdoi:10.1515/PTERIDINES-2020-0028Teodor T. PostolacheDeborah R. MedoffClayton H. BrownLi Juan Fang
Lipohilic statins impair the viability of primary hATF in culture by induction of intrinsic apoptotic pathways whereas hydrophilic statins do not affect hATF viability. This could be due to the hydrophilic characteristic of the molecule, preve
Hydrophilic statins (pravastatin, rosuvastatin) may cause less muscular events than lipophilic statins (e.g. simvastatin, atorvastatin) due to lower passive diffusion into muscle cells. Objective To compare the risk of muscular events between statins at comparable lipid-lowering doses and to evaluate ...
Combination treatment with two different types of statins at the correct dose may be a promising approach to neuroprotection following CA/CPR.Nakayama, ShinDepartment of Anesthesiology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanTaguchi, Noriko...
Chang C-H, Hsu Y-M, Chen Y-C, et al. Anti-inflammatory effects of hydrophilic and lipophilic statins with hyaluronic acid against LPS-induced inflammation in porcine articular chondrocytes. J Orthop Res. 2014;32:557-65.Chang CH, Hsu YM, Chen YC, et al. Anti-inflammatory effects of ...
Kato S,Smalley S,Sadarangani A, et al.Lipophilic but not hydrophilic statins selectively induce cell death in gynecological cancers expressing high levels of HMGCoA reductase. Journal of Cellular and Molecular Medicine . 2009Kato S, Smalley S, Sadarangani A, Chen-Lin K, Oliva B, Bra- nes J...