48 002 controls in 5 genome-wide association studies, genetic elevation of low-density lipoprotein cholesterol and triglyceride levels were associated with an elevated risk of abdominal aortic aneurysm and high-density lipoprotein cholesterol level was associated with a lower risk of abdominal aortic ...
P-value was calculated using one-sided Wilcoxon test. Source data are provided as a Source Data file. Full size image To verify the assignment of lipids to the main neural cell types, we first compared the human data to the two published mouse datasets, each covering eight of the 75 ...
These disorders affect every field of medicine, including reproductive biology, inflammation, cancer, diabetes, cardiovascular disease, and obesity. Therefore, to maintain a normal physiological state, the spatial and temporal activity of nuclear receptors must be tightly controlled by tissue-specific ...
Transparent Testalo (TT16), a transcript regulator belonging to the B sister MADS box proteins, regulates proper endothelial differentiation and proanthocyanidin accumulation in the seed coat. Our understanding of its other physiological roles, however, is limited. In this study, the physiological and...
A solid-supported lipid bilayer was also used to test for the lipophilicity of various drug candidates [48]. As some pharmaceuticals must traverse the cell membrane to be effective, lipophilicity is an important property that should be tested for early in the drug development cycle. By using mod...
Recently introduced drugs and test substances have been found to modulate hyperfiltration. The following provides an overview of established treatments, recently introduced drugs, and novel compounds. 10.1. The Renin-Angiotensin-Aldosterone System (RAAS) Angiotensin converting enzyme inhibitors (ACEi) and ...
a role for these proteins in lipid transport in vivo. Such a result may be due simply to our present inability to duplicate the necessary conditions to achieve this transport in the test tube. Alternatively, the activity of these proteins in the intact cell may actually be exchange of lipids...
Given these findings, there is growing evidence for a role for PUFA synthesis in supporting tumorigenesis within the GBM microenvironment. FADS1 and FADS2 are essential for GBM CSC survival and maintenance To functionally test the requirement for FADS1 and FADS2 activity in CSCs, we ...
A two-sided t-test was used for statistical analysis (*P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001). Source data Full size image Regarding molecular lipid composition, FA shifts can be observed toward a more unsaturated membrane (Fig. 4d,e). However, this is mainly due to ...
and then lipid ROS were assayed.a,dEach western blot data is representative of three independent experiments, data were presented as mean ± SD, statistical significance was analyzed using one-way ANOVA with Dunnett’s multiple comparisons test, (a) or unpaired two-tailed T-test (d).b,e...