ResearchOpen Access30 Nov 2024Communications Biology Volume: 7, P: 1597 MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities Lipids are complex molecules crucial for life. The authors developed MS-DIAL 5, a tool that enhances in-depth structure elucidations and the spati...
Valm, A. M. et al. Applying systems-level spectral imaging and analysis to reveal the organelle interactome. Nature 546, 162–167 (2017). Article CAS PubMed PubMed Central Google Scholar Thiam, A. R., Farese, R. V. & Walther, T. C. The biophysics and cell biology of lipid droplet...
where alllipid moleculesare connected by their hydrophobic chains. We placed this structure in a larger water box to make a dilute solution of lipids, which was used as the starting configuration of CG-MD of a dilute lipid solution. In this way, we can observe spontaneous transformation of li...
This ability gives rise to exciting phenomena, ranging from lateral modulations of membrane structure to morphological phase transitions. Our understanding is challenged because membrane-biopolymer interactions are ultimately relevant in biology and biotechnology. The present chapter focuses entirely on elastic...
apolipoproteins, which stabilize the structure and determine the functionality of lipoproteins. The core of lipoproteins contains non-polar lipids, primarily TGs, and sterol esters. Each class of lipoprotein possesses a unique function in delivering lipids to tissues. Chylomicrons are synthesized in ...
Cytokine Receptor Structure, Cytokines, Deep Learning in Pathology, Dehydrogenase, Developmental biology, Diabetes Mellitus, Diagnostic Immunology, Disease Biology, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Drug Carrier Design, Drug Delivery Platform Technology, Drug Discovery Chemist...
in vivo, impacting on oncogenic c-Myc signaling pathway [89]. The inhibition of FABPs family, particularly FABP5, altered cell structure, inflammatory and metabolic pathways, clearly impacting on the mitochondrial membrane potential, oxygen consumption rates and FA oxidation (Fig.1B) [90]....
The corpus luteum, a unique and transient structure, is vital for female reproductive function. BECN1 is a key autophagy regulator that promotes the storage of neutral lipids in corpus luteum cells. Its gene knockout in mouse ovarian granulosa cells significantly reduces LD accumulation in luteal ...
Lipids in biological membranes are thought to be functionally organized, but few experimental tools can probe nanoscale membrane structure. Using brominated lipids as contrast probes for cryo-EM and a model ESCRT-III membrane-remodeling system composed o
Our lipid structure elucidation refers to “FA acyl/alkyl level” according to the proposed lipid nomenclature65 or to “putatively characterized compound classes (level 2)” according to the metabolomics standard initiative66. It implies that sn-attachments of FA, positions of double bounds, and st...