NanoparticlemRNASizeLipidLipid nanoparticles (LNP) are effective delivery vehicles for messenger RNA (mRNA) and have shown promise for vaccine applications. Yet there are no published reports detailing how LNP biophysical properties can impact vaccine performance. In our hands, a retrospective analysis ...
Biomaterials for Nanoparticle Vaccine Delivery Systems In particular, we focus on the impact of biomaterials composition, size, and surface charge of nanoparticles on modulation of particle biodistribution, ... P Sahdev,L Ochyl,J Moon - 《Pharmaceutical Research》 被引量: 121发表: 2014年 Stable RN...
et al. Development of the iLiNP device: fine tuning the lipid nanoparticle size within 10 nm for drug delivery. ACS Omega 3, 5044–5051 (2018). Article CAS PubMed PubMed Central Google Scholar Li, H. J. et al. Stimuli-responsive clustered nanoparticles for improved tumor penetration and...
Nanoparticle size was measured using dynamic light scattering with Zetasizer Nano ZPS (Malvern). Preparing washed platelets Approval for the study was obtained from the ethics boards of the University of British Columbia (UBC) and the Canadian Blood Services (CBS), in accordance with the UBC and ...
SOLID LIPID NANOPARTICLE AS DRUG DELIVERY SYSTEM: AN OVERVIEW efficiently.1 Development of solid lipid nanoparticles is one of the emerging fields of uniquesize-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics Microemulsion based method12,18,19 Gasco and ... ...
At a weight ratio of 1.25:1 StMA to lipid, the nanoparticle size created is 28 + 1 nm for a 2:1 ratio, 10 + 1 nm for a 3:1 StMA ratio and 32 + 1 nm for a 4:1 StMA ratio independent of the molecular weight of the polymer. Due to the polymer acting as a surfactant ...
The optimized batch revealed spherical morphology under TEM analysis with particle size of 202 : 6 +/- 1 : 65 nm and 0 : 334 +/- 0 : 987 PDI. The zeta potential and % EE were found to be -33 : 6 +/- 0 : 845 mV and 68 : 89% +/- 0 : 59 respectively. Lyophilized powder...
Lipid nanoparticle (LNP)-formulated mRNA vaccines were rapidly developed and deployed in response to the SARS-CoV-2 pandemic. Due to the labile nature of mRNA, identifying impurities that could affect product stability and efficacy is crucial to the long-term use of nucleic-acid based medicines....
Ocular delivery of lipid nanoparticle (LNPs) packaged mRNA can enable efficient gene delivery and editing. We generated LNP variants through the inclusion of positively charged-amine-modified polyethylene glycol (PEG)-lipids (LNPa), negatively charged-carboxyl-(LNPz) and carboxy-ester (LNPx) modifie...
A multifunctional lipid nanoparticle for co-delivery of paclitaxel and curcumin for targeted delivery and enhanced cytotoxicity in multidrug resistant brea... The objective of the work was to develop a multifunctional nanomedicine based on a folate-conjugated lipid nanoparticles loaded with paclitaxel and...