20,21 Its development also allows the identification of products of the lipid metabolism pathway involved in the pathogenesis of NAFLD.20 In addition, the suggestion of combining lipidomics analysis with machine learning also opens the future of predicting possible risks depending on the disease ...
Nakamura Y, Koizumi R, Shui G, Shimojima M, Wenk MR, Ito T, Ohta H (2009) Arabidopsis lipins mediate eukaryotic pathway of lipid metabolism and cope critically with phosphate starvation. Proc Natl Acad Sci U S A 106:20978–20983 Article CAS PubMed PubMed Central Google Scholar Napier ...
Nature Metabolism volume 1, pages 1127–1140 (2019)Cite this article 2068 Accesses 20 Citations 31 Altmetric Metrics details Abstract Although mammalian target of rapamycin 1 (mTORC1) negatively regulates autophagy in cultured cells, how autophagy impacts mTORC1 signalling, in particular in an in ...
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in colorectal cancer (CRC) evolution has not been reported. ...
AD cortical lipid metabolism disorder was associated with the dysregulation of the PPAR signaling pathway, glycerophospholipid metabolism, adipocytokine signaling pathway, fatty acid biosynthesis, fatty acid degradation, ferroptosis, biosynthesis of unsaturated fatty acids, and fatty acid elongation. Candidate ...
Targeting cell metabolism offers promising opportunities for the development of drugs to treat cancer. We previously found that the fatty acyl-CoA synthetase VL3 (ACSVL3) is elevated in malignant brain tumor tissues and involved in tumorigenesis. This study investigates the role of ACSVL3 in the...
acta neuropathol commun (2021) 9:101 https://doi.org/10.1186/s40478-021-01205-7 RESEARCH Open Access Altered lipid metabolism marks glioblastoma stem and non‑stem cells in separate tumor niches Sajina Shakya1, Anthony D. Gromovsky2, James S. Hale2,3, Arnon M. ...
Sphingolipid metabolism correlates with cerebrospinal fluid Beta amyloid levels in Alzheimer’s disease. PLoS ONE. 2015;10(5):e0125597. Article PubMed PubMed Central Google Scholar Zhao L, Spassieva S, Gable K, Gupta SD, Shi LY, Wang J, Bielawski J, Hicks WL, Krebs MP, Naggert J, ...
Effects of Di-(2-ethylhexyl) Phthalate on Lipid Metabolism by the JAK/STAT Pathway in Rats. Int J Environ Res Public Health, 2016; 13, 1085. doi: 10.3390/ijerph13111085 [21] Derecka M, Gornicka A, Koralov SB, et al. Tyk2 and Stat3 regulate brown adipose tissue differentiation and ...
Mitochondria are major source of reactive oxygen species (ROS), which activates multiple oncogenic signaling pathways, such as Akt signaling, during tumor progression30. Considering that Akt/mTOR pathway has been well established to play a central role in the regulation of cell lipid metabolism31,32...