AD cortical lipid metabolism disorder was associated with the dysregulation of the PPAR signaling pathway, glycerophospholipid metabolism, adipocytokine signaling pathway, fatty acid biosynthesis, fatty acid degradation, ferroptosis, biosynthesis of unsaturated fatty acids, and fatty acid elongation. Candidate ...
20,21 Its development also allows the identification of products of the lipid metabolism pathway involved in the pathogenesis of NAFLD.20 In addition, the suggestion of combining lipidomics analysis with machine learning also opens the future of predicting possible risks depending on the disease ...
Given that lipid metabolism plays a critical role in supporting cancer progression and remodeling the tumor microenvironment, targeting the lipid metabolism pathway could provide a novel approach to cancer treatment. This review seeks to: (1) clarify the overall landscape and mechanisms of lipid ...
ECI2 proteins promote the re-entry of enoyl coenzyme A into the β-oxidation cycle3and also participate in peroxisomal lipid metabolism4,5. There are still relatively few studies on the relevant functions of ECI family proteins in tumors6. Ether lipids (including alkyl acyl phospholipids and enoy...
nucleotides as well as for the synthesis of substrates for TCA cycle [25,26]. Similarly, the elevated PPP and serine synthesis pathway sustain bortezomib resistance due to the increased anti-oxidant capacity in MM cells. Targeting serine metabolism can therefore enhance the sensitivity to bortezomib...
In addition to these well-established roles, lipids are now recognized to critically contribute to brain energy metabolism26, cell type differentiation27,28, neuronal and glial signaling28,29,30, control of inflammatory response31 and modulation of protein complexes32. Furthermore, alterations in the...
Di-(2-ethylhexyl) phthalate induces ferroptosis in prepubertal mouse testes via the lipid metabolism pathway alterations in prepubertal testes, and testicular lipidomics indicated notable alterations in lipid metabolism and significant enrichment of ferroptosis. Further... X Wang,D Li,Xiangqin ZhengYifan...
Targeting cell metabolism offers promising opportunities for the development of drugs to treat cancer. We previously found that the fatty acyl-CoA synthetase VL3 (ACSVL3) is elevated in malignant brain tumor tissues and involved in tumorigenesis. This study investigates the role of ACSVL3 in the...
Mitochondria are major source of reactive oxygen species (ROS), which activates multiple oncogenic signaling pathways, such as Akt signaling, during tumor progression30. Considering that Akt/mTOR pathway has been well established to play a central role in the regulation of cell lipid metabolism31,32...
6e and Supplementary Data 4), of which purine metabolism is the major biological pathway included in this annotation. Compared to control AEC2 cells, Mfn1/2-deletion in AEC2 cells activated profound ATF5-mediated UPRMT, and ATF4-mediated stress response pathways (Supplementary Fig. 12a), along ...