Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsib
The results indicate that: (1) there is strong evidence for increased lipid metabolism in THCA and KICH. (2) Although the overall levels of lipid metabolic processes are down-regulated in some cancer types, fatty acid synthase activity and fatty acid elongation are moderately up-regulated in ...
This latter indirectly blocks LD biogenesis and lipophagy. Prostaglandin E2 metabolism Targeting COX2 or PGE2 receptors has beneficial effects on progression of multiple cancers [138,139,140,141,142]. For example, in cisplatin-resistant OvCA cells, overexpression of PGE2 receptor, EP3, constitutes an...
Hyperactive lipid metabolism is closely associated with cancer progression and unfavorable outcomes. The underlying mechanisms are being gradually deciphered. In this review, we aim to summarize recent advances on how reprogrammed lipid metabolism and accompanying signaling cascades directly modulate cancer ...
The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders Article Open access 08 February 2022 Lipid droplets: platforms with multiple functions in cancer hallmarks Article Open access 06 February 2020 Loss of hepatic Flcn protects against fibrosis an...
Lipid metabolism in cancer cells has garnered increasing attention in recent decades. Cancer cells thrive in hypoxic conditions, nutrient deficiency, and oxidative stress and cannot be separated from alterations in lipid metabolism. Therefore, cancer cells exhibit increased lipid metabolism, lipid uptake,...
lipid droplets(LDs)predominantly in aggressive cancer cells and their microenvironment,such as the cancer cells and microenvironment in Zajdela ascites hepatoma... P Schwartsburd - 癌症通讯(英文) 被引量: 0发表: 2022年 Lipid metabolism and lipophagy in cancer The tumor microenvironment can be hypoxi...
This review focuses on novel findings related to nuclear receptor signaling – including the vitamin D receptor and the liver receptor homolog 1 – in hepatic lipid and glucose uptake, storage and metabolism in the clinical context of NAFLD, liver regeneration, and cancer. Download: Download high-...
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Considering the central role of lipid metabolism in regulating ferroptosis, we next studied lipid compositional changes in cell cycle–arrested cells by conducting untargeted lipidomic analyses of Caki-1 cells treated with a vehicle or nocodazole. Treatment with nocodazole resulted in a global increase ...