Lipid metabolism changes occur in early Alzheimer's disease (AD) patients. Yet little is known about metabolic gene changes in early AD cortex. The lipid metabolic genes selected from two datasets (GSE39420 and GSE118553) were analyzed with enrichme
3C). KEGG analysis indicated that DEMLRGs were related to “metabolic pathways”, “inositol phosphate metabolism”, and “glycerophospholipid metabolism” (Fig. 3D). Reactome analysis suggested that DELMRGs were significantly enriched in “metabolism of lipids”, “metabolism”, and “metabolism of ...
Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent immuno-metabolic disease that can progress to hepatic cirrhosis and cancer. NAFLD pathogenesis is extremely complex and is characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation...
Comparison of gene sets with respect to functional categories revealed a higher gene number assigned to the category “carbohydrate metabolic process” and in “fatty acid biosynthetic process” in M. neglectum when compared to Chlamydomonas reinhardtii and Nannochloropsis gaditana, indicating a higher ...
Reprogrammed lipid metabolism of cancer cells not only supplies appropriated energy, but also plays a central role in ferroptosis12. Among the metabolic process, the desaturation is of profound interest, since it is supposed to (1) prevent lipotoxicity from excess saturated fatty acyl chains, (2...
(Table S5B), respectively. A large number of KEGG-annotated genes were enriched in various metabolic processes, including carbohydrate metabolism, amino-acid metabolism, metabolism of cofactors and vitamins, nucleotide metabolism, and energy metabolism (Fig. S2C), while the eggNOG-annotated genes ...
the 16S rRNA gene sequencing technology has been widely employed for microbiota analysis due to its high sensitivity and short time consumption [20], while UHPLC-Q-TOF-MS/MS based lipidomics analysis enables accurate reflection changes in lipid metabolite levels and biological lipid metabolic network...
RNA sequencing analysis showed 24 differentially expressed (DE) miRNA, and GO and KEGG analysis demonstrated that the DE miRNAs were significantly enriched in lipid metabolic process, lipid storage, Wnt, mTOR, and PPAR signaling pathways. miR-34a was found to be increased in the H group and ...
Fig. 1: Metabolic landscape of patients with hyperlipidemia and hypertension. a Overview of the study design. b, c Counts and classes of metabolites detected by metabolomics in human serum. d The heatmap shows the different metabolites between the different groups. e KEGG analysis of differentially...
As expected, due to the changes seen in the lipidomics work, many pathways involving fatty acid metabolism were found in both GO and KEGG gene sets (i.e. GO gene set lipid metabolic process and KEGG gene set biosynthesis of unsaturated fatty acids). Interestingly, translation was exclusively ...