Lipid metabolism changes occur in early Alzheimer's disease (AD) patients. Yet little is known about metabolic gene changes in early AD cortex. The lipid metabolic genes selected from two datasets (GSE39420 and GSE118553) were analyzed with enrichme
The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses revealed the association of these differentially expressed genes with functions and pathways related to lipid metabolism. Finally, we established a scoring model of lipid metabolis...
In order to elucidate the underlying methods contributing to the different findings identified by the risk score model, a KEGG pathway examination was performed. The findings of this analysis revealed that the most significantly activated pathways in the high-risk class were related to metabolism, inc...
neglectum, as well as the metabolic reconstruction of crucial lipid pathways, provides new insights into the diversity of the lipid metabolism in microalgae. The results of this work provide a platform to encourage the development of this strain for biotechnological applications and production concepts...
KEGG: Kyoto Encyclopedia of Genes and Genomes pathway LASSO: least absolute shrinkage and selection operator LMRGs: lipid metabolism-related genes PPI: protein‒protein interaction RMSE: root-mean-square error SVM-RFE: support vector machine recursive feature elimination TF: transcription facto...
KEGG pathway enrichment analysis revealed that the DEGs in AT/MD were mainly enriched in starch and sucrose metabolism, lipid metabolism, plant-pathogen interaction, plant hormone signal transduction. The DEGs in AT/CK were mainly enriched in fructose and mannose metabolism, starch and sucrose ...
(p < 0.01 and FDR<0.2) were metabolism related, of which the most significant one was “triglyceride biosynthetic process”. The KEGG pathway analysis indicated the down-regulation of several fat metabolic pathways as well. Thus, we utilized mRNA data from our previous study17, which was ...
A KEGG enrichment analysis; B–E GSEA analysis; F–I The heat-map of differentially expressed genes in glycolysis/gluconeogenesis, pyruvate metabolism, PPAR signaling pathway, and insulin signaling pathway Full size image Notably, our comprehensive analysis of the above differential gene KEGG-enriched ...
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in color
Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quantification in