Gene expression profiles of GSE143272 from blood samples were included for differential analysis, and the lipid metabolism–related differentially expressed genes (DEGs) were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. The...
How to cite this article: Miao, X.et al.Genome-wide analysis of microRNAs identifies the lipid metabolism pathway to be a defining factor in adipose tissue from different sheep.Sci. Rep.5, 18470; doi: 10.1038/srep18470 (2015).
A KEGG enrichment analysis; B–E GSEA analysis; F–I The heat-map of differentially expressed genes in glycolysis/gluconeogenesis, pyruvate metabolism, PPAR signaling pathway, and insulin signaling pathway Full size image Notably, our comprehensive analysis of the above differential gene KEGG-enriched ...
we performed RNA-seq, GO analysis, and KEGG enrichment analysis. The pathway with the highest enrichment score was found to be the downregulated cytokine-cytokine receptor interaction pathway (Fig.3aand Supplementary Fig.2a). The genes of this pathway were mapped as heatmaps (Fig.3b). RT-qPCR...
In order to elucidate the underlying methods contributing to the different findings identified by the risk score model, a KEGG pathway examination was performed. The findings of this analysis revealed that the most significantly activated pathways in the high-risk class were related to metabolism, inc...
Given the bidirectional impact of immunity on the composition and function of the microbiota, our study delved into the influence of genetic background on the composition of the GM, the fatty acid metabolism and the immune response in fast and slow-progressing SOD1 G93A mouse models. Our findin...
Lipidomics Pathway & Network Analysis: Mapping lipid metabolism pathways and interactions Biomarker Discovery: Identifying lipid-based biomarkers for disease diagnosis and prognosis Deliverables 1. Experiment Procedures 2. Parameters of Liquid Chromatography and Mass Spectrometer 3. MS Raw Data Files 4. MS...
neglectum, as well as the metabolic reconstruction of crucial lipid pathways, provides new insights into the diversity of the lipid metabolism in microalgae. The results of this work provide a platform to encourage the development of this strain for biotechnological applications and production concepts...
Twelve ORENZA orphan enzymes are members of the KEGG ether lipid metabolism pathway (KEGG release 61.1, February 1, 2012). Due to the lipophilic nature of the substrates, many enzymes involved in the ether lipid biosynthetic pathway are integral membrane enzymes. These enzymes are often especially...
The clinical benefit of tyrosine kinase inhibitors (TKIs)-based systemic therapy for advanced hepatocellular carcinoma (HCC) is limited due to drug resistance. Here, we uncover that lipid metabolism reprogramming mediated by unconventional prefoldin RPB5