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Subsequently, we performed colony survival experiments of TC-NER KO cell lines in response to a 1 h pulse of FA. Whereas all TC-NER KO cells showed an equal sensitivity to UV irradiation, onlyCSAandCSBKO cells displayed a strong hypersensitivity to FA (Fig.4cand Extended Data Fig.5c,d)...
Because potato is highly heterozygous, a large number of traits segregate every time a cross is made. Every offspring receives a unique combination of desirable alleles at some loci and undesirable alleles at others. No offspring is ever “perfect.” An issue of considerable practical importance, ...
(42.55% and 42.64%, respectively;P=0.91). We also aligned all high-quality reads to the prototypic repeat sequences in the RepBase Update database and again determined the amount of methylated and total number of reads per consensus sequence CpG using custom software19. For each repeat type,...
The Allele Translations table provides a key or legend linking the newly "translated" genotype to the original size in base-pairs score. Future exports use identical "allele translation codes." New alleles identified after the first export will be added to the end of a marker's allele ...
To verify the conditional nature of the allele, we infected Hmga2CK/+ and Hmga2CK/CK MEFs with an adenoviral vector expressing Cre. Cre expression converted the CK alleles to their GFP conformation, with infected cells expressing high levels of GFP and lacking full-length Hmga2 protein (...
Such alleles tend to be maintained at an intermediate frequency in populations by way of the process known as balancing selection. Positive selection favors the fixation of beneficial mutations that lead to evolution of new traits. Therefore, a mutation is said to be adaptive if it performs a ...
The first column needs to be unique identifiers for strains. Each of the remaining rows presents a different strain.Use '-' or '0' to represent missing alleles.Aligned FASTAAn aligned FASTA file contains multiple sequences of the same length in FASTA format. Many sequence alignment tools, e....
Isolated nucleic acids encoding therapeutic proteins comprise a nucleic acid sequence encoding a therapeutic protein and subsequences, interspecies homologues, alleles and polymorphic variants thereof. To obtain high level expression of a cloned gene, such as those cDNAs encoding a suitable monoclonal ...
frequently occurs in people suffering from AA. In a new study published inHaematologica, the group shows that these HLA-A and HLA-B alleles contain the common nonsense mutation, which is a change in the gene's DNA sequence that causes the blood cells to stop making the HLA protein ...