通过这一系列的筛选和验证实验,作者提出了图示模型:lincRNA-p21 由 p53 直接激活,在 p53 依赖的凋亡通路中相关基因的抑制起到了重要作用,并且与 hnRNP-K 这个反式作用因子直接相互作用来共同完成该调控功能。除了该工作中所涉及的 p53 通路,lincRNA-p21还被发现可能参与癌症中的重要通路,因此,通过本文这一个linc...
【LincRNA-P21能抑制血管动脉粥样硬化】 国内一项研究发现,冠心病患者其血液中LincRNA-P21的含量普遍较低,绝大部分只有正常人的1/4。进一步研究表明,动脉粥样硬化血管该RNA的含量同样非常低。通过实验结果证实,该RNA含量是影响冠心病发病进程的原因之一。 k...
KEGG分析发现,lincRNA-p21过表达和基因敲减对酒精暴露小鼠肠道菌群功能的影响涉及氨基酸代谢、脂质代谢、营养物质消化吸收以及细胞生长和死亡等方面。结论lincRNA-p21过表达能够加重酒精性肠道损伤,而敲减lincRNA-p21则可减轻酒精性肠道损伤,其机制可能与增加或减轻肠道屏障损伤以及改变肠道菌群结构有关。 【总页数】5页...
noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes JR Hall1,2,3, ZJ Messenger1,3, HW Tam1,3, SL Phillips4, L Recio4 and RC Smart*,1,2,3 LincRNA-p21 is a long noncoding RNA and a transcriptional target of p53 and HIF-1...
LincRNA-p21是p53基因下游的转录本,研究表明,LincRNA-p21异常表达在多种肿瘤的发生发展中发挥着重要作用,但其在食管癌中的作用机制仍披着一层神秘的面纱。本研究拟探索LincRNA-p21与食管癌发病关系及机制。目的:1.比较分析食管癌细胞EC109、EC9706和食管永生化上皮细胞Het-1A,以及食管癌组织和配对癌旁组织中Linc...
ING1b is a tumor suppressor that affects transcription, cell cycle control and apoptosis. ING1b is deregulated in disease, and its activity is closely linked to that of p53. In addition to regulating protein-coding genes, we found that ING1b also influen
lincRNA-p21的表达水平与其匹配的癌旁正常组织相比明显下降(P0.01),而相反,GLS表达水平显著高于配对癌旁组织(P0.01).过表达lincRNA-p21能显著性抑制膀胱癌细胞增殖(P0.05)及生长(P0.01),且抑制谷氨酰胺酶表达(P0.05),从而抑制谷氨酰胺代谢水平降低(P0.05),代谢产物下降(P0.05).相反,沉默lincRNA-p21会促进膀胱...
(P < 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.001 andP = 0.002, respectively). The serum lincRNA-p21 level was not signif i cantly dif f erent between patients withHBV negative liver metastatic cancer and the normal control (P =0.80). LincRNA-p21 level...
Bao X, Wu H, Zhu X et al (2015) The p53-induced lincRNA- p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell Res 25:80-92Bao X, Wu H, Zhu X, et al. The p53-induced lincRNA-p21 derails somatic cell reprogramming by...