Next, the up-regulation of lncRNA p21 and miR-181b was used as a reversal experiment, and the results suggested that the up-regulation of miR-181b attenuated the promoting effect of lncRNA p21 and Tnfaip1 on apoptosis and inflammatory response, which may be related to the activation of ...
与model组相比,sh-LncRNA p21组小鼠血管弹力纤维断裂及损伤程度减轻,LncRNA p21、MMP-2、MMP-9、caspase-3表达和细胞凋亡率均降低(P<0.01),TIMP-1、cyclinD1和YAP、TAZ表达均增加(P<0.01)。结论 LncRNA p21能够促进小鼠AAA形成,其机制与调控Hippo-YAP信号、促进细胞凋亡、抑制细胞增殖相关。 【总页数】8页(...
血清lncRNA P21、lncRNA H19在妊娠期糖尿病患者血清和胎盘组织中表达及意义 均显著高于单纯妊娠期高血压组，同时重度子痫前期组的ＡＣＲ水平均显著高于轻度子痫前期组和单纯妊娠期高血压组，ＡＣＲ水平与ＣＣＲ的表达呈负相关，提示ＡＣＲ水平与病情严重程度密切相关，可用于评估ＰＩＨ患者肾损伤程度。单因素分析...
目的 探讨LncRNA-p21调控Notch信号通路对非小细胞肺癌A549细胞增殖、迁移及侵袭的影响。 方法 pcDNA-lincRNA-p21、空载质粒pcDNA转染A549细胞设为过表达组和空载组;稳定转染过表达组加入Notch信号通路特异性激活剂Jagged1蛋白,设为Notch激活剂组;不作处理细胞为对照组。MTT法、划痕实验和Transwell小室实验检测各组细胞...
RNA immunoprecipitation (RIP) and chromatin immunoprecipitation (ChIP) assay revealed that LINC00968 recruit EZH2 to the promoter of p21 to inhibit its expression. In summary, our results support the conclusion that lncRNA LINC00968 accelerates the proliferation and fibrosis of mesangial cells by ...
另外,LINC00525还通过与RNA结合基序单链相互作用蛋白2(RNA binding motif single stranded interacting protein 2,RBMS2)竞争性结合,促进p21 mRNA的衰变,从而在转录后水平抑制p21的表达.结论我们的研究结果表明,LINC00525与EZH2和RBMS2协同降低p21 mRNA的转录和稳定性,从而促进LUAD的进展,表明LINC00525可能是LUAD临床...
Glioma is the most common malignant tumor in the central nervous system. Altered long noncoding RNAs (lncRNAs) are playing regulatory roles in physiological and pathogenic processes in cancer. Here, we uncovered a differentially expressed lncRNA called b
Our findings suggested that the pseudogene-derived from lncRNA DUXAP10 drove the biological progression of ESCC. DUXAP10 was likely to be a potential therapeutic target for ESCC. 展开 关键词: DUXAP10 ESCC EZH2 p21 proliferation DOI: 10.1080/15384047.2018.1470723 ...
lncRNA GAS5 was shown to interact with Y-box binding protein 1 (YBX1) and lncRNA GAS5 knockdown was shown to accelerate YBX1 protein turnover without affecting YBX1 transcription. lncRNA GAS5 down-regulation reduced the YBX1 protein level, which decreased YBX1-transactivated p21 expression ...
LncRNA-SNHG16 predicts poor prognosis and promotes tumor proliferation through epigenetically silencing p21 in bladder cancer. Cancer Gene Ther. 2018; 25: 10-7.Cao X, Xu J, Yue D. LncRNA-SNHG16 predicts poor prognosis and promotes tumor proliferation through epigenetically silencing p21 in...