Mechanism dissection revealed that Enz could promote the lncRNA-p21 transcription via altering the androgen receptor (AR) binding to different androgen-response-elements, which switch the EZH2 function from histone-methyltransferase to non-histone methyltransferase, consequently methylating the STAT3 to ...
目的 探讨LncRNA-p21调控Notch信号通路对非小细胞肺癌A549细胞增殖、迁移及侵袭的影响。 方法 pcDNA-lincRNA-p21、空载质粒pcDNA转染A549细胞设为过表达组和空载组;稳定转染过表达组加入Notch信号通路特异性激活剂Jagged1蛋白,设为Notch激活剂组;不作处理细胞为对照组。MTT法、划痕实验和Transwell小室实验检测各组细胞...
术后随访3年,采用Kaplan-Meier绘制不同LncRNA-p21表达肺腺癌患者生存曲线,Cox比例风险模型分析影响肺腺癌患者预后的因素.结果肺腺癌组织LncRNA-p21相对表达量低于癌旁组织(1.03±0.27 vs 3.02±0.81,P<0.05),其中,肿瘤直径≥3 cm,低中度分化,T_(3)期,N_(2)期患者LncRNA-p21相对表达量低于肿瘤直径<3 cm,...
Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with prostate cancer. 展开 关键词: prostate cancer exosome lncRNA Benign prostatic hyperplasia Non-invasive diagnosis ...
项目名称 lncRNA-p21/EZH2通路促进前列腺癌神经内分泌化的机制研究学科学类 H1619 医学科学部_肿瘤学_泌尿系统肿瘤项目批准号 81802521资助类型 青年科学基金项目资助经费 22万元项目负责人 罗杰职称 暂无批准年份 2018单位名称 同济大学起止时间 2019-01至2021-12项目中文摘要 暂无...
Our findings suggested that the pseudogene-derived from lncRNA DUXAP10 drove the biological progression of ESCC. DUXAP10 was likely to be a potential therapeutic target for ESCC. 展开 关键词: DUXAP10 p21 EZH2 proliferation ESCC DOI: 10.1080/15384047.2018.1470723 ...
通过沉默 GUARDIN 、 LRP130 或 pgc1 α 来破坏该复合物的稳定性,导致 FOXO4 的表达增加并上调其靶基因 p21,从而驱动细胞衰老。我们还发现 GUARDIN 的表达是由雷帕霉素诱导的,雷帕霉素是一种抑制细胞衰老的药物。FOS 样抗原 2 (FOSL2) 作为 GUARDIN 的转录抑制因子,对雷帕霉素反应的较低 FOSL2 水平与 ...
Glioma is the most common malignant tumor in the central nervous system. Altered long noncoding RNAs (lncRNAs) are playing regulatory roles in physiological and pathogenic processes in cancer. Here, we uncovered a differentially expressed lncRNA called b
lncRNA GAS5 was shown to interact with Y-box binding protein 1 (YBX1) and lncRNA GAS5 knockdown was shown to accelerate YBX1 protein turnover without affecting YBX1 transcription. lncRNA GAS5 down-regulation reduced the YBX1 protein level, which decreased YBX1-transactivated p21 expression ...
表2各组细胞lncRNA-GAS5、c-Myc、GSTM3和P21表达的比较(n=6, ±s) 注:GSTM3为谷胱甘肽-S-转移酶Mu3,lncRNA-GAS5为长链非编码RNA-生长阻滞特异性转录因子5 注:GSTM3为谷胱甘肽-S-转移酶Mu3 图1Western blot法检测细胞c-Myc、GSTM3和P21表达的电泳图 ...