lncRNA-p21WNT/Β-CATENIN信号通路胃癌转移目的:探讨lncRNA-p21在调控胃癌MGC-803细胞生长与转移作用中的作用及Wnt/β-catenin信号通路在其中的功能.方法:在人胃癌MGC-803细胞中转染慢病毒以过表达lncRNA-p21.观察细胞形态,细胞增殖以及体内外迁移和侵袭能力,检测Wnt/β-catenin信号通路是否参与lncRNA-p21介导的抑制...
Mechanism dissection revealed that Enz could promote the lncRNA-p21 transcription via altering the androgen receptor (AR) binding to different androgen-response-elements, which switch the EZH2 function from histone-methyltransferase to non-histone methyltransferase, consequently methylating the STAT3 to ...
LncRNA-p21在体内外均抑制了胃癌MGC-803细胞增殖和生长,体外实验表现为lncRNA-p21过表达减弱了胃癌MGC-803细胞迁移和侵袭能力。LiCl实验验证了Wnt/β-catenin信号通路介导了lncRNA-p21对胃癌MGC-803细胞增殖、迁移与侵袭的抑制作用。结论:LncRNA-p21可在体内外显著抑制胃癌MGC-803细胞的生长与转移,且该抑制作用可能...
血清lncRNA P21、lncRNA H19在妊娠期糖尿病患者血清和胎盘组织中表达及意义 均显著高于单纯妊娠期高血压组，同时重度子痫前期组的ＡＣＲ水平均显著高于轻度子痫前期组和单纯妊娠期高血压组，ＡＣＲ水平与ＣＣＲ的表达呈负相关，提示ＡＣＲ水平与病情严重程度密切相关，可用于评估ＰＩＨ患者肾损伤程度。单因素分析...
术后随访3年,采用Kaplan-Meier绘制不同LncRNA-p21表达肺腺癌患者生存曲线,Cox比例风险模型分析影响肺腺癌患者预后的因素.结果肺腺癌组织LncRNA-p21相对表达量低于癌旁组织(1.03±0.27 vs 3.02±0.81,P<0.05),其中,肿瘤直径≥3 cm,低中度分化,T_(3)期,N_(2)期患者LncRNA-p21相对表达量低于肿瘤直径<3 cm,...
Our findings suggested that the pseudogene-derived from lncRNA DUXAP10 drove the biological progression of ESCC. DUXAP10 was likely to be a potential therapeutic target for ESCC. 展开 关键词: DUXAP10 p21 EZH2 proliferation ESCC DOI: 10.1080/15384047.2018.1470723 ...
RNA immunoprecipitation (RIP) and chromatin immunoprecipitation (ChIP) assay revealed that LINC00968 recruit EZH2 to the promoter of p21 to inhibit its expression. In summary, our results support the conclusion that lncRNA LINC00968 accelerates the proliferation and fibrosis of mesangial cells by ...
lncRNA GAS5 was shown to interact with Y-box binding protein 1 (YBX1) and lncRNA GAS5 knockdown was shown to accelerate YBX1 protein turnover without affecting YBX1 transcription. lncRNA GAS5 down-regulation reduced the YBX1 protein level, which decreased YBX1-transactivated p21 expression ...
Glioma is the most common malignant tumor in the central nervous system. Altered long noncoding RNAs (lncRNAs) are playing regulatory roles in physiological and pathogenic processes in cancer. Here, we uncovered a differentially expressed lncRNA called b
采用细胞学和分子标记方法对甜瓜属人工异源四倍体(C. hytivus Chen and Kirkbride,2n = 4x = 38)的亲本染色体组间的交换重组进行了研究。通过对减数分裂中期 ... 庄飞云,CHENJin-feng,钱春桃,... - 《中国农业科学》 被引量: 50发表: 2005年 甜瓜属人工异源四倍体Cucumis×hytivus早期世代表型与基因表达变化...