产品介绍 :The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms ...
The LIM domain is a modular protein-binding interface that is found in a wide variety of eukaryotic proteins with diverse biological functions. The LIM domain can be identified by a conserved sequence: C(X)2C(X)16–23(H/C)X2,4(C/H/E)(X)2C(X)2C(X)14–21(C/H)(X)2/1/3(C...
specificity. Despite their structural similarity to GATA-type, DNA-binding zinc-fingers LIM domains do not bind DNA and instead mediate protein–protein interactions[31]. In proteins with multiple LIM domains, each LIM domain is connected by a flexible linker, with no preference in the spatial or...
Although individual transcription factors initiating progression remain unknown, LIM-only protein (LMO) and LIM-domain binding protein (LDB) negatively regulate breast carcinoma cell differentiation. In this study, we investigated the expression of LMO4 and LDB in squamous cell carcinomas of the oral ...
2.3.1Ldb1, LIM domain-binding 1 LIM domain-bindingprotein 1or LIM-domain binding 1 (Ldb1) (Agulnick et al., 1996), also known as nuclear interactor (NLI) (Jurata, Kenny, & Gill, 1996) or CLIM2 (Bach, Carrière, Ostendorff, Andersen, & Rosenfeld, 1997), was identified by protein...
The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–extracellular matrix interaction and adhesion. Here, we report that deleting Pinch1 in limb mesenchymal stem cells (MSCs) and Pinch2 globally (double knockout; dKO) in mice causes severe chondrodysplasia, while single...
LIM-domain protein cysteineand glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of... R Weiskirchen,M Moser,S Weiskirchen,... - 《Biochemical Journal》 被引量: 132发表: 2001年 The expression of CSRP2 encoding the LIM...
Turner;J;Nicholas;H;Bishop;D;Matthews;J;M;Crossley;M.The LIM protein FHL3 binds basic Kruppel-like factor/Kruppel-like factor 3 and its co-repressor C-terminal- binding protein 2.Journal of Biological Chemistry.2003Turner J,Nicholas H,Bishop D,Matthews J M,Crossley M.The LIM protein FHL3...
The serine- and leucine-rich DENN protein possesses a RGD cellular adhesion motif and a leucine-zipper-like motif associated with protein dimerization, and shows partial homology to the receptor binding domain of tumor necrosis factor alpha. DENN is virtually identical to MADD, a human MAP kinase...
1) LIM domain LIM结构域1. The LIM domain is found in a wide variety of eukaryotic proteins that regulate gene expression and cell differ-entiation during development. 通过BLAST分析发现该基因编码的家蚕肌肉LIM蛋白,含有5个保守的LIM结构域,家蚕的另一种LIM蛋白(AAR23823)含一个LIM结构域,两者可能是...