Recently, a number of two LIM-domain containing proteins (LIMs) have been reported to trigger the formation of actin bundles, a major higher-order cytoskeletal assembly. Here, we analyzed the six Arabidopsis thaliana LIM proteins. Promoter-尾-glucuronidase reporter studies revealed that WLIM1, WLI...
In vitro human cancer cell line studies suggested that the PDZ-LIM domain-containing protein PDLIM2, also known as SLIM or mystique11,12,13, may function as a tumor suppressor14,15,16,17,18,19,20. The main function of PDLIM2 is to promote ubiquitination and proteasomal degradation of nuc...
The LIM domain-dependent localization of the adapter protein paxillin to β3 integrin-positive focal adhesions (FAs) is not mechanistically understood. Here, by combining molecular biology, photoactivation and FA-isolation experiments, we demonstrate specific contributions of each LIM domain of paxillin ...
It is composed solely of LIM domains, protein-protein interaction modules (Schmeichel and Beckerle, 1994) found in diverse actin cytoskeleton-associated proteins (Smith et al., 2014) and homeobox transcription factors (Kadrmas and Beckerle, 2004). Many LIM-domain containing proteins exhibit ...
LIM domain only 3 (LMO3) interacts with transcription factors to regulate target genes involved in embryonic development. The oncogenic role of LMO3 in hepatocellular carcinoma, gastric cancer, and neuroblastoma has been reported recently. However, littl
LIMK1 is a type of serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Synonyms for this target antigen include LIMK and LIM motif-containing protein kinase. LIMK1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish...
纯化方法 Protein A purified类型 Monoclonal Antibody 同种型 IgG 储存/保存方法 Store at -80℃ for one year.靶标 背景说明 Anti-CD223 Reference Antibody(Relatlimab) is expressed from CHO. The heavy chain type is huIgG4SP, and the light chain type is hukappa. It has a predicted MW of...
Through interaction with cellular proteins, LIM domain-containing proteins (LIM proteins) regulate many cellular processes. We and others have shown that expression of four-and-a-half LIM domain protein 1 (FHL1), characterized by four complete LIM domains preceded by an N-terminal half LIM ...
C. The LIM domain: from the cytoskeleton to the nucleus. Nat Rev Mol Cell Biol 5, 920–931 (2004). Article CAS PubMed Google Scholar Zheng, Q. & Zhao, Y. The diverse biofunctions of LIM domain proteins: determined by subcellular localization and protein-protein interaction. Biol Cell ...
It can then bind to LIM 3 and 4 of paxillin and subsequently to the SH3 domain of p130Cas and dephosphorylate tyrosine residues (pY) on p130Cas essential for binding SH2 domain containing protein (such as Crk). By dephosphorylating p130Cas, PTP-PEST is believed to inhibit downstream ...