LIM domain containing proteins are often found at sites of cell adhesion and have been implicated in regulating adhesion. Here, I report on the role of the LIM protein, Ajuba in cell adhesion and motility.;In primary keratinocytes, Ajuba is recruited to cadherin-dependent cell-cell adhesive ...
et al. The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling. Cancer Res 67, 9097–9106 (2007). Article CAS PubMed Google Scholar Hou, Z. et al. The LIM protein AJUBA recruits protein arginine methyltransferase 5 to ...
We have previously implicated the LIM (LIN-1, ISL-1, MEC-1) domain protein Ajuba as a new player in the ATR pathway14. The LIM superfamily of proteins, constituted by 60 members in the human proteome, is subdivided into seventeen families, all with predicted LIM domains in various ...
Ajuba is a member of the LIM protein family characterized by containing tandem LIM domains at the C termini. The LIM domain is a double zinc-fingers in structure and was initially identified inCaenorhabditis elegansLin-11, rat Isl-1 andC. elegansMec-3, from which the acronym LIM was derived...
Additionally, the use of the selective inhibitors MC1293 (HDAC1i) and GSK126 (EZH2i) also prevented Runx2 mRNA suppression in MM treated pre-OB.The LIM-domain protein family member Ajuba was reported to serve as a Gfi1 corepressor on a subset of Gfi1 target genes in macrophages. Therefore...
subfamily members LMO1-LMO4) and LIM-only proteins that display a dual cellular localization behavior (e.g. cysteine-rich proteins (CRP), particularly interesting new cysteine-histidine protein (PINCH), Zyxin, Ajuba, iipoma preferred partner (LPP), Trip6, and Four-and-a-Half LIM domain (FHL...
(SRF). A MADS-domain-containing transcription factor that binds to the serum-response element in the promoter-enhancer region of many genes. PROTEASOME A protein complex that is responsible for degrading intracellular proteins that have been tagged for destruction by the addition of ubiquitin. ...
the nuclear isoform of the LIM-domain protein TRIP6, in the temporal control of myogenesis. In an in vitro model of myogenesis, the expression of nTRIP6 is transiently up-regulated at the transition between proliferation and differentiation, whereas that of the cytosolic isoform TRIP6 is not alt...