In the December 2009 issue of Hospital Pharmacy, the Special Feature section provided a list of light-sensitive oral prescription drugs. We appreciate that this updated list was published, especially in light of the fact that we authored the list that appears to have been the basis for the ...
We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate receptors in the control of pain. Optical activation of systemic JF-NP-26, a caged, normally inactive, negative allosteric modulator (NAM) of mGlu5 receptors, in cingulate, prelimbic, and inf...
Psychiatry.1. a method of treating certain mental disorders by inducing sleep through barbiturates.2. a type of psychotherapy involving the use of hypnotic drugs. Also narcoanalysis. — narcotherapist, n. noctambulism somnambulism. Also noctambulation. — noctambulist, noctambule, n. — noctambul...
A cell scatters light both as a large particle and as a collection of small particles reflecting its internal composition, hence both forward and large‐angle light scattering are volume sensitive, although the latter appears to be the more sensitive method (Latimer, 1982; McManus et al., 1993...
Cur NDs exhibited different optical properties, light-sensitive, drug release behavior and this resulted in an increased ROS generation and PDT efficacy on cancer cells compared with free Cur. Moreover, cell apoptosis during Cur NDs-based PDT was related to the activation of the ROS-mediated JNK...
To analyze the sensitive parameters of the model, we identified the parameters with higher than 80% absolute correlation to the outputs of interest, (Fig. 3I–L). For tumor killing, we found that for low doses, the binding rate of CD3 receptors was more important for driving killing, becau...
Recently, multiple drugs were shown to act on the same cell lines in a first-of-its-kind study72. To aid in effective cancer treatments which concurrently activate tumor suppressors and inactivate oncogenes, novel drug-combination therapies are required. For this reason, we validated the predicted...
whether the contribution of changes in circadian clocks to the aetiology of mood disorders is only negative, or whether changes in sleep-wake timing are also a positive response, aimed at sheltering from activity-related light exposure at times when the circadian system is most sensitive to light...
2.3. Light sensitive ion channels and calcium It is quite clear that there must be some other type of photoacceptor, in addition to CCO, as is clearly demonstrated by the fact that wavelengths substantially longer than the red/NIR wavelengths discussed above, can also produce beneficial effects ...
“stimuli-responsive” materials as constituents of the capsule shell. Among a wide range of factors that induce the release of the core material, we focus herein on the light stimulus. In polymers, this feature can be achieved introducing a photo-sensitive segment, whose activation leads to ...