In the December 2009 issue of Hospital Pharmacy, the Special Feature section provided a list of light-sensitive oral prescription drugs. We appreciate that this updated list was published, especially in light of the fact that we authored the list that appears to have been the basis for the ...
We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate receptors in the control of pain. Optical activation of systemic JF-NP-26, a caged, normally inactive, negative allosteric modulator (NAM) of mGlu5 receptors, in cingulate, prelimbic, and inf...
Cur NDs exhibited different optical properties, light-sensitive, drug release behavior and this resulted in an increased ROS generation and PDT efficacy on cancer cells compared with free Cur. Moreover, cell apoptosis during Cur NDs-based PDT was related to the activation of the ROS-mediated JNK...
2.3. Light sensitive ion channels and calcium It is quite clear that there must be some other type of photoacceptor, in addition to CCO, as is clearly demonstrated by the fact that wavelengths substantially longer than the red/NIR wavelengths discussed above, can also produce beneficial effects ...
whether the contribution of changes in circadian clocks to the aetiology of mood disorders is only negative, or whether changes in sleep-wake timing are also a positive response, aimed at sheltering from activity-related light exposure at times when the circadian system is most sensitive to light...
To analyze the sensitive parameters of the model, we identified the parameters with higher than 80% absolute correlation to the outputs of interest, (Fig. 3I–L). For tumor killing, we found that for low doses, the binding rate of CD3 receptors was more important for driving killing, becau...
Recently, multiple drugs were shown to act on the same cell lines in a first-of-its-kind study72. To aid in effective cancer treatments which concurrently activate tumor suppressors and inactivate oncogenes, novel drug-combination therapies are required. For this reason, we validated the predicted...
And I think that such faith is degree-sensitive. The greater is one’s faith and belief, the quicker the clearing and healing. THE COLLECTIVE UNIFIED CREATING FIELD Could this field-dynamic also be at work on a collective level, such as in the Body of Mankind as a unified whole having ...
A Synechocystis mutant lacking all four of these HL-inducible proteins has been reported, which is sensitive to HL (He et al., 2001; Xu et al., 2004). The presence of twice as many CAB genes in Nodularia CCY9414 compared with Synechocystis suggests that these proteins may have important ...
In addition, users must establish procedures to ensure that there is independent data verification before relying on such data in sensitive or critical operations. Users should periodically check IBM's support websites for updated information and fixes applicable to the system and related software. ...