Twitter Google Share on Facebook ligand (redirected fromLigands) Thesaurus Medical Encyclopedia li·gand (lī′gənd, lĭg′ənd) n. An ion, molecule, or molecular group that binds to another chemical entity to form a larger complex. ...
Recent structural and functional data now suggest that the activation and desensitization gates are distinct, and are located at both sides of the ion channel. Such a "dual gate mechanism" accounts for the marked allosteric effects of channel blockers, a feature illustrated herein by theoretical ...
Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel Xiaolong Gao Philipp A. M. Schmidpeter Crina M. Nimigean Nature Communications(2022) Sections Figures References Advertisement Nature Structural & Molecular Biology (Nat Struct Mol Biol)ISSN1545...
Together, our results provide critical insights into the mechanistic principles by which ligand-binding allosterically gates InsP3R channel. 展开 DOI: 10.1038/s41422-018-0108-5 年份: 2018 收藏 引用 批量引用 报错 分享 全部来源 求助全文 Nature 相似文献Cryo-EM Reveals Ligand Induced Allostery Underlyi...
The authors expect this system to have potential in areas such as chemo sensing, logic gates and volatile organic compound (VOC) monitoring. A memory device was also generated using [Pt(36)Cl][N(PPh3)2] as the active material which exhibited stable binary memory performance with long ...
In addition to mediating excitatory amino acid transport, hEAAT2 also acts as an anion-selective channel27,28,29. The hEAAT2-associated current includes three components: glutamate-induced anion current, Na+-dependent anion leak current, and glutamate transport current30,31. The competitive inhibito...
Ligand-gated ion channel Ligand-gated ion channel Ligand-Gated Ion Channel Superfamily Ligand-Induced Binding Site 2 Ligand-Inducible Binding Sites Ligand-Protein Contact ligand-sensitive channel Ligand-to-Ligand Charge Transfer Ligand-to-Metal Charge Transfer ligandin Ligands Ligands Ligands Ligar Ligar...
If authentic or synthetic standards for specific molecules were not available, molecules with similar physical and chromatographic features were used as surro- gates. Linear calibration curves were obtained for each LM, which gave R2 values of 0.98–0.99. 2.1 | Human blister fluid Few low-risk ...
To study how the 5-HT3AR gates, the substituted cysteine accessibility method (SCAM) was employed to determine the conformational rearrangements that occur within the pore upon ligand binding and subsequent receptor activation. By looking at the pattern of cysteine modification using thiol-modifying ...
G. et al. Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature 466, 272–275 (2010). 44. Gupta, S. et al. Conformational changes during the gating of a potassium channel revealed by structural mass spectrometry. Structure 18, 839–846 (2010...