Most obviously, males range from a tiny fraction of the size of females to considerably larger and live considerably shorter to substantially longer lives (Austad, 2006, Finch, 1990). Sex differences in longevity can potentially be exploited to help understand mechanisms underlying variation in ...
Clement Finch to first hypothesize the existence of signals released by mature erythroid cells that controls iron metabolism. This hypothesis has been recently confirmed by the identification of erythroferrone (ERFE), a protein released by erythroid cells that suppresses hepcidin expression in mice under...
2006). The inverse correlation between metabolic rate and longevity in Drosophila has been reported in a number of studies. It has been suggested that poikilotherms can have their lifespan extended or curtailed as their metabolic rates are decreased or increased, respectively (Finch 1990; Rose ...
Finch CE. Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proc Natl Acad Sci U S A. 2010;107 Suppl. 1:1718-24.Finch CE. 2010. Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition....
PERSPECTIVE Lifespan and mitochondrial control of neurodegeneration Alan F Wright1, Samuel G Jacobson2, Artur V Cideciyan2, Alejandro J Roman2, Xinhua Shu1, Dafni Vlachantoni1, Roderick R McInnes3 & Rudolph A Riemersma4 We examine the allometric (comparative scaling) relationships between rates ...
a cost of reproduction in terms of shortened post-reproductive lifespan at high parities. Therefore, as fertility decreased over time, female lifespan increased, while male lifespan remained largely stable, supporting the theory that differential costs of reproduction in the two sexes result in the...
of ageing and, more specifically, the evolution of human ageing. Historical aspects of this evolution will be discussed. Evidence from a variety of sources shows that the human lifespan is increasing, and may well continue to increase to levels that are difficult to predict. In addition, the ...
DG Morgan,PC May,CE Finch - 《Journal of the American Geriatrics Society》 被引量: 420发表: 1987年 Neural plasticity in the dynamics of human visual word recognition Repeated exposure to words leads to plastic changes in the nervous system throughout the lifespan, with the consequence that com...
Differential coexpression is a change in coexpression between genes that may reflect 'rewiring' of transcriptional networks. It has previously been hypothesized that such changes might be occurring over time in the lifespan of an organism. While both coe
Finch, C. E. Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation and nutrition. Proceedings of the National Academy of Sciences 107, 1718–1724 (2010). Article CAS ADS Google Scholar Fontana, L., Partridge, L. & Longo, V. D. Extending Healthy Life ...