This Review covers the current status and controversies surrounding the potential of sirtuins as novel pharmacological targets, with a focus on SIRT1. Abstract Although the increased lifespan of our populations illustrates the success of modern medicine, the risk of developing many diseases increases ex...
We should ensure that the space for production is used intensively and efficiently, that the living space is livable and proper in size, and that the ecological space is unspoiled and beautiful; and we should leave more space for nature to achieve self-renewal. We should keep more farmland fo...
Full size image To determine the evolutionary pathways connecting the three states of social organization within mammals, we tested four models that allowed the transition rates between any of two states to vary differently. These four alternative models were: (a) the equal rates model (ER), in...
powerful landscape images: sharp, primal stones in the foreground, with pinsharp bursts of color in the form of beautifully textured lichens and mosses. The contrast of colour picks out further texture. At eye level, the large size of the print gives the image a solidity and power that invit...
A: Mike Gillette has created a program specifically designed to take ANYONE regardless of age, size or ability and transform them into a weapon against an attacker. Unlike martial arts and other combat sports, REAL LIFE Self-Defense doesn’t rely on spending hours and hours learning complex, ...
Malaysia needs to commit itself to the basic principle of human rights, the preservation of lives, and join the growing numbers of countries that had abolished death penalty from its laws or practice. Currently 140 countries had abolished death penalty in its laws or practice. ...
Full size image Distribution of kisspeptin in the limbic system Kisspeptin-expressing neurones and mRNA have been identified in the bed nucleus of the stria terminalis (BNST), thalamus, and amygdala of rodents [22]. Furthermore, amygdala kisspeptin expression is positively modulated by gonadal sex ...
Am I preparing the students, not only for the next level of English, but also, am I adequately conveying that I care even more about the type of people they are becoming? Am I making that personal connection that communicates to them that their life matters and is important?
7, 2003, file photo, a section of a human brain with Alzheimer's disease is on display at the Museum of Neuroanatomy at the University at Buffalo, in Buffalo, N.Y. There are no proven ways to stave off Alzheimer's, but a new report raises the prospect that avoiding nine ris...
The large sample size and thorough collection of lifestyle behaviors from this nationally representative survey of older Chinese individuals allowed us to prospectively evaluate the association between healthy lifestyle and becoming a centenarian in individuals of advanced age (≥80 years). This study ...