This Review covers the current status and controversies surrounding the potential of sirtuins as novel pharmacological targets, with a focus on SIRT1. Abstract Although the increased lifespan of our populations illustrates the success of modern medicine, the risk of developing many diseases increases ex...
GraphPad PRISM was used for all statistical analyses. When measuring the difference between two populations, we used a standard Student’st-test. No statistical tests were used to predetermine sample size and no animals were excluded from results. Animal ethics statement All of the protocols for an...
傍晚时雄虫和雌虫聚在一起 In the evening both males and females gather 雄虫开始大眼瞪小眼地 and the males begin to size one another up, 彼此打量 eyeball to eyeball. 两眼间距最宽的凸眼蝇 Having the widest eye span 就可以称老大 puts you at the top of the pecking order. 眼柄不是武器 ...
On the evening of July 7, Shanghai resident Chen Yuanyuan was out on an after-dinner walk on a cobble-stone path in her residential area, wearing pants and slippers, when a racoon dog (Nyctereutes procyonoides) the size of a cat darted through the high grass. The animal scratched the...
. Obviously, diverse “recipients” of information would not react to one and the same message in a similar way; however, weak interactions ensure delivering of a message to a large “audience”, actually to the whole system, so that the instructions and commands would not miss their t...
Four-chambered stomach including the forestomachs (rumen, reticulum, and omasum) and abomasum allows ruminants convert plant fiber into high-quality animal products. The early development of this four-chambered stomach is crucial for the health and well-
In life science, cell culture in vivo involves animal experiments, which are difficult to observe and increases the complexity. Therefore, the combination of microfluidic technology and cell culture in vitro has gradually attraction scientists’ attention. In recent years, microfluidic cell culture has ...
Sign in to download full-size image Figure 5.4.Configuration of a typical whole-building LCA tool. Main data can be inputted in a spreadsheet format, or through a geometric computer model. Geometric based input uses the 3D model software platform to extract information about the building’s mate...
Discerning the relationship between sociality and longevity would permit a deeper understanding of how animal life history evolved. Here, we perform a phylogenetic comparative analysis of ~1000 mammalian species on three states of social organization (solitary, pair-living, and group-living) and longevi...
Full size image L2-Cmu treatment improves female cardiac function Given the reported importance of IGF-1 signaling to the myocardium27,28, we next assessed the effects of IGF-1R antagonism on cardiovascular function by echocardiography (Fig.4). Cardiac aging in mice is characterized by a decline...