Cancer stem cells drive metastasis - The Scientist - Magazine of the Life SciencesJeffrey M. PerkelThe ScientistScientist
Cancer stem cells (CSCs), are thought to be at the origin of tumor development and resistance to therapies. Thus, a better understanding of the molecular mechanisms involved in the control of CSC stemness is essential to the design of more effective therapies for cancer patients. Cancer cell s...
Many tumors are now understood to be heterogenous cell populations arising from a minority of epithelial-like cancer stem cells (CSCs). CSCs demonstrate distinctive metabolic signatures from the more differentiated surrounding tumor bulk that confer resistance to traditional chemotherapeutic regimens and pote...
7. Licochalcone A inhibits hypoxia-inducible factor-1α accumulation by suppressing mitochondrial respiration in hypoxic cancer cells: M.K. Park, et al.; Biomed. Pharmacother. 133, 111082 (2021) NUCLEAR-ID®Blue DNA stain (GFP-CERTIFIED®) 产品特点 ● 蓝色荧光特异性DNA染料 ● 稳定且纯度高 ...
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Two new ontologies, including the Cancer Cell Ontology (CCL) and the Ontology for Stem Cell Investigations (OSCI), were reported in the workshop. In another representation, the Cell Line Ontology (CLO) framework was applied and extended to represent cell line cells used in China and their ...
Cannabinoid CB1and CB2receptors differentially regulate TNF-α-induced apoptosis and LPA1-mediated pro-survival signaling in HT22 hippocampal cells Maria C. Olianas, Simona Dedoni, Pierluigi Onali Article 119407 select article RETRACTED: miR-98-5p inhibits gastric cancer cell stemness and chemoresistanc...
Study reveals blueprint for child-specific cancer immunotherapies A study led by Professor Petter Brodin, a pediatrician and immunologist at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London, analyzed 191 children aged 0 to 18, all diagnosed with various solid tumors at Stock...
their clinical applications are limited by rapid degradation by nucleases and difficulties in targeting cancer cells. In this study, we have developed a Rhein-loaded aptamer-based DNA nanotube (DNT-S6@Rhein) for the targeted and efficient therapy of non-small cell lung cancer. Through the palindro...
Modeling stem cell derived cell lines will continue to be a difficult challenge. The multiple possible end prod- ucts resulting from the unique characteristics of in vitro stem cell cultures such as those seen in work on induced pluripotent stem cells introduce complexity to the knowledge modeling ...