Cancer stem cells drive metastasis - The Scientist - Magazine of the Life SciencesJeffrey M. PerkelThe ScientistScientist
Current evidence indicates that a subpopulation of cancer cells, named cancer stem cells (CSCs) or tumor-initiating cells, are responsible for the initiation, growth, metastasis, therapy resistance and recurrence of cancers. CSCs share core regulatory pathways with normal stem cells; however, CSCs re...
What immune cells eat can determine how well they do their job byClara Rodriguez Fernandez|Dec 30, 2024|Health,Life Science A new link between what cells feed on and their gene activity could have huge implications in cancer research and beyond. ...
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Many tumors are now understood to be heterogenous cell populations arising from a minority of epithelial-like cancer stem cells (CSCs). CSCs demonstrate distinctive metabolic signatures from the more differentiated surrounding tumor bulk that confer resistance to traditional chemotherapeutic regimens and pote...
Immune checkpoints in tumor microenvironment and their relevance to the development of cancer stem cells Neda Khosravi, Ahad Mokhtarzadeh, Amir Baghbanzadeh, Khalil Hajiasgharzadeh, ... Behzad Baradaran Article 118005 select article Roles of long non-coding RNAs in cervical cancer ...
Guide to Seeding, Expanding, and Harvesting Stem Cells This whitepaper leverages Corning’s extensive expertise in seeding, expanding, and harvesting stem cells. Download Whitepaper Guide to Extracellular Vesicles With more efficient and consistent production methods, researchers will be able to harness ...
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Interestingly, the unbalanced competition between the coactivator CBP/p300 for CREB1 and p65 leads to the activation of the NF-κB pathway in cells with CREB1 disrupted, which induces an obvious EMT phenotype of the cancer cells. Taken together, these studies identify previously unknown mechanisms ...
FMRP acts as a regulator of a network of genes (IL-33, PROS1) and cells (Treg, M2 macrophages and potentially additional classes of myeloid cells) in the tumor microenvironment that helps cancer cells to evade immune destruction.AdipoGen Life Sciences provides many unique reagents to study ...