This book chapter presents a concise overview of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. It explores viral classification based on morphology and nucleic acid composition with a focus on DNA and RNA viruses , the SARS-CoV-2 structure including the structural as well as ...
Fig. 1. Strategies to block key steps of the life cycle of SARS-CoV-2. Multiple steps in the life cycle of the virus are presented, including the binding of the spike protein to ACE2, membrane fusion between the virus and the host cell, release of the viral RNA, translation of the ...
The replication cycle of SARS-CoV-2 explained based on current literature. We provide a graphical representation of the SARS-CoV-2 Life Cycle with its St...
Infection with SARs-COV-2 displays increasing fatality with age and underlying co-morbidity, in particular, with markers of the metabolic syndrome and diabetes, which seems to be associated with a “cytokine storm” and an altered immune response. This suggests that a key contributory factor could...
The life cycle of viruses can differ greatly between species and category of virus, but they follow the same basic stages for viral replication. The viral life cycle can be divided into several major stages: attachment, entry, uncoating, replication, maturation, an...
We previously developed a deterministic mathematical model that describes the life cycle of SARS-CoV-2 in the form of ordinary differential equations (ODE) [19]. The model considers major replication stages including the binding of the virus to the ACE2 receptor, the translation of nonstructural ...
According to a review of the literature, the spectrum of identified genes showed that the virus post-transcriptionally promotes or represses the genes involved in the SARS-CoV-2 life cycle. The identified genes/proteins are also involved in adaptive immunity, in the function of the cilia and ...
一些病毒基因组包含产生自身复制蛋白的指令,如黄热病病毒(正义RNA病毒)和SARS-CoV-2冠状病毒(正义RNA病毒)中的RNA依赖的RNA聚合酶(RdRP)[10]。像mRNA一样,+ ssRNA(单链RNA)病毒可以立即被宿主细胞核糖体翻译,无需将RNA依赖的RNA聚合酶(RdRp)带入细胞 。带有双链RNA (dsRNA)、负...
Pandemic coronavirus disease 2019 (COVID‐19), caused by SARS‐CoV‐2 virus, mainly affects adult or aging individuals with fever, dry cough and dyspnea of variable severity. In ~20% of patients, a widespread alveolar‐interstitial pneumonia develops with acute respiratory distress syndrome. With ...
mammalian cells employ an array of mechanisms to repair the damaged DNA. Repair pathways can also trigger cell cycle blockade, stress responses, and apoptosis. BPS Bioscience has a broad selection of tools for your work on DNA damage and repair including PARPtrapTMassay kits, active proteins, re...