It appears that EBV has perfected a clever strategy to overcome transcriptional repression of its many lytic genes to initiate virus de novo within a few hours after induction of its lytic cycle. This review tries to summarize the known molecular mechanisms, the current models, concepts, and ...
The Cancer Genome Atlas whole-transcriptome sequencing (WTS) data to investigate EBV infection by life cycle information using three-step LiEB workflow: 1) characterize virus infection generally; 2) align transcriptome sequences against a hybrid human-EBV genome, and 3) quantify EBV gene expression....
The tripartite life cycle of EBV. Infection and pre-latent phase (light blue segment). Upon infection, a virion releases it epigenetically naïve linear DNA (red) into its host cell. The viral DNA circularizes and makes its way into the nucleus (light green). As the incoming DNA is not...
10. The role of the DDR in KSHV lytic replication 11. Latent and lytic KSHV proteins contribute to genomic instability 12. Epstein-Barr virus 13. The role of the DDR during EBV establishment and latency 14. The role of the DDR during EBV lytic reactivation 15. EBV induces DNA damage and...
Getting adequate sleep is a critical part of the daily cycle of renewing bodily functions. Yet, many folks experience sleep deprivation; and those that do often tend to brush off its signs. Such signs include tossing around on the bed or staring at the ceiling at night, still feeling exhaust...
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After primary infection, the Epstein‐Barr virus (EBV), a ubiquitous herpesvirus, establishes a life‐long latent infection. EBV can establish a delicate balance to regulate its proliferation and host cell survival. Owing to the limited gene products of EBV, interfering with the host PTM machinery...
of the life cycle is made. KSHV life cycle contains two phases of infection: a short lytic replication and a persistent latent replication. During latency, LANA protein tethers KSHV episome to host cell chromosome and partitions certain numbers of genome copies to new cells. Upon exogenous ...
viruses Review Role of Host Cell Secretory Machinery in Zika Virus Life Cycle Garrett Sager 1, Samuel Gabaglio 2, Elizabeth Sztul 1,* and George A. Belov 2,* 1 Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, ...