Yes, solvents used for LiAlH4 should be dried.Toluene,ether also can be used as solvent.Added to this,LiAlH4 should be handled in inert atmosphere(ex.N2/argon)For better clarity check the MSDS of LiAlH4. Logged discodermolide Chemist Sr. Member Posts: 5038 Mole Snacks: +405/-70 Gend...
This mechanism is for a LiAlH4 reduction. The mechanism for a NaBH4 reduction is the same except methanol is the proton source used in the second step. 1) Nucleophilic attack by the hydride anion 2) The alkoxide is protonated Going from Reactants to Products Simplified Properties of hydri...
Addition of LiAlH4 to aldehydes to give primary alcohols Description:Addition of lithium aluminum hydride to aldehydes leads to formation of primary alcohols (after addition of acid) Comments
Four TS structures corresponding to axial and equatorial attacks by LiAlH4 were located for each ketone conformer. Electronic potential maps were used to investigate the substituent electronic effect on the TS stabilization. The uneven carbonyl orbital distribution in the LUMO (蟺*) was also analyzed...
I think LAH is a very hard nucleophile and will attac the carbonyl much faster. I should ad that for beta-nitrostyrenes 1,4-addition is faster than reduction of the nitro group so maybe you will get a mixture? Also RLi is a very hard nucleophile but attacks the C=O with 1,2 additi...
The 1~H NMR spectra of cyclic carbonates and acetals of secondary-secondary glycolicsystems can be used to estimate the ratio of erythro and threo isomers... X Liu,X Pan,LI Yulin,... - 《Chinese Journal of Organic Chemistry》 被引量: 1发表: 1988年 Pinacol...