The 尾2-integrin lymphocyte function-associated antigen-1 (LFA-1) plays a crucial role within the immune system. It regulates the interaction between T cells and antigen-presenting cells and facilitates T-cell adhesion to the endothelium, a process that is important for lymphocyte extravasation and...
unction in T cells. Cell surface ADP-ribosyltransferase regulates lymphocyte function-associated molecule-1(LFA-1) function in T cells.Cell surface ADP-ribosyltransferase regulates lymphocyte function-associated molecule-1(LFA-1) function in T cells.gamma delta T cell receptor...
petre bm,walz t,springer ta.global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling.cell.2002;110:599-611;zhang k,chen j.the regulation of integrin function by divalent cations.cell adh migr.2012;6(1):20-29...
The integrin LFA-1 is crucial for T-cell/ APC interactions and sensitive recognition of antigens. Precise nanoscale organization and valency regulation of LFA-1 are mandatory for an appropriate function of the immune system. While the inside-out signals regulating the LFA-1 affinity are well desc...
cells ( mB M_ E C s ) .The ad h esion a n d transmigration through endot h el i a l cells of t h e HPP— EPC s block ed by functiona l g r a de neutraliz ing a n t i bodie s of V L A - 4 a n d L F A 一 1 were studi ed fn vi tro.T hw ere po sit...
Whether and, if so, how Mg2+ availability in tissues is sensed and integrated functionally by CD8+ T cells has not been investigated. Results First, we explored how Mg2+ affected memory CD8+ T cell function in vitro, using complete media containing 1.2 mM Mg2+ versus no Mg2+ as the only...
Heterodimers of CD18 and the a subunits are expressed broadly by all leukocytes with NK and T cells showing higher density of surface expression. Through the interactions of LFA-1, Mac-1 and gp150/95 with their counter-receptors, CD18 is involved in cellular adhesion and the immune resp...
Mac-1 and gp150/95. Heterodimers of CD18 and the a subunits are expressed broadly by all leukocytes with NK and T cells showing higher density of surface expression. Through the interactions of LFA-1, Mac-1 and gp150/95 with their counter-receptors, CD18 is involved in cellular adhesion...
In mice, they only account for 3% of decidual leukocytes on embryonic day 8.59. T cell extravasation from the well-vascularized feto-maternal interface is strictly regulated. As T cells depend on active leukocyte function-associated antigen (LFA)−1 for adhesion to, rolling on and ...
ICAM-1/LFA-1 interactions function-associated antigen-1/ICAM-1 interactions in T cell ac- in T-lymphocyte activation and adhesion to cells of the blood- tivation cannot be overcome by expression of high density TCR retina barrier in the rat. Immunology 1994; 83(1): 52-7. ligand. J ...