It has, however, equally acquired a bad name for producing some intolerable and disabling side effects, such as various forms of dyskinesias and severe postural hypotension, and in many cases total withdrawal of therapy is indicated. One may wonder if many of these cases are really due to ...
retrieval or execution of complex motor tasks that can occur as a result of disease progression or as short- or long-term side effects of levodopa ... Giladi,McMahon,Przedborski,... - 《Neurology》 被引量: 576发表: 1992年 Complications of chronic levodopa therapy: long-term efficacy of dru...
Effects of intestinal Levodopa infusion on freezing of gait in Parkinson disease. J Neurol Sci. 2018;385:105–8. Article CAS PubMed Google Scholar Merola A, Espay AJ, Romagnolo A, et al. Advanced therapies in Parkinson’s disease: long-term retrospective study. Parkinsonism Relat Disord. ...
E. L-Dopa: its clinical effects in parkinsonism. Trans. Am. Neurol. Assoc. 93, 56–63 (1968). CAS PubMed Google Scholar Melamed, E. Early-morning dystonia. A late side effect of long-term levodopa therapy in Parkinson's disease. Arch. Neurol. 36, 308–310 (1979). Article CAS ...
and as consequence of this an up and down of dopamine concentrations with pulsatile stimulation of postsynapticdopamine receptorssupport onset of these initial predictable and later unpredictable fluctuations of movement. These motor side effects of long-terml-dopa therapy initiated a long debate on the...
[16]Clinicians should discontinue the medication in patients that experience excessive daytime sleepiness. Long-term use of levodopa presents can lead to other complications. The patients' quality of life can be negatively affected because of irreversible motor function changes from drug use. These ...
The long-term consequences of the use of these supplements by healthy individuals remains to be seen. Adhesion DOPA is a key molecule in the formation of marine adhesive proteins, such as those found in mussels. It is believed to be responsible for the water-resistance and rapid curing ...
Short-term side effects of levodopa can include nausea, hypotension, and hallucinations, while long-term complications can include motor fluctuations and dyskinesias.4 Some of the short-term side effects can be man- aged by coadministration of a peripheral decarboxylase inhibitor, such as carbidopa ...
This randomized clinical trial assesses the long-term effects on patient-rated quality of life of adjuvant treatment with dopamine reuptake inhibitors
To our knowledge, L-3,4-dihydroxyphenylalanine (L- dopa) continues to be the chief choice for symptomatic treatment associated with PD even if its long-term use leads to the development of debilitating side effects such as choreic, dystonic, and ballistic movements, collectively referred to as...