dependentmanner,andtheproteinwasover-expressedduringthestepwiseacquisitionofazoleresistance.However,disruptionorectopicoverexpressionofCalPF14030didnotaffectthesensitivityofCalbicanstoazoles.Finally,wedemonstratedthatdisruptionofCalPF14030significantlyincreasedintracel‘lularATPIevels.andoverexpressionsignificantlydecreasedjntr...
Protein O-GlcNAcylation, a dynamic and reversible glucose-dependent post-translational modification of serine and threonine residues on target proteins, has been proposed to promote vascular smooth muscle cell proliferation and migration events implicated in vein graft failure (VGF). Therefore, targeting ...
Studies have found that high-protein diets can improve BMI status in overweight and obese children in the short-term [111], but a high protein intake in early life increases the risk of later obesity [112]. However, several studies have shown that this is likely due to increased fat-free...
In modeling approaches, utilizing this point of view, every possible state of a protein is described by a variable of its own. As signaling systems contain many such molecules, each with a large number of domains, one often faces a combinatorial explosion of the number of states[3]. For ex...