Four animal models with mutations in the glycine receptor's gene support the importance of this subunit in the pathogenesis of hyperekplexia. Three of these are lines of mutant mice with a recessively inherited startle syndrome. In the “spasmodic” mouse, a missense mutation in the α1subunit...
A diagnosis of myelopathy was established based on the presence of hyperreflexia, including a positive Hoffmann sign, upper extremity sensory disturbance and obvious MRI-documented cervical spinal cord compression. Sensory and motor nerve conduction velocities in the peripheral nerves were within normal ...
Of the 14 patients with sacral injuries, 12 (85.7%) manifested areflexia, 11 (78.6%) had low compliance, and 12 (85.7%) had high leak point pressures. Of the 33 patients with combined suprasacral and sacral injuries, urodynamic studies showed 23 with hyperreflexia and/or detrusor ...