What is Leukopenia? Discussion Comments ByMonika— On Jun 10, 2011 What an interesting article. The last time I was sick my doctor kept throwing around the term "leukocytes count" and I had no idea what he was talking about! I might have had more of a clue had I known leukocytes were...
Human neutrophil lipocalin (HNL) is a specific granule constituent of the neutrophil granulocyte. Studies in bronchial and lung parenchymal tissue and peri... LactoferrinOncogene ProteinsProto-Oncogene ProteinsMicroscopy, ImmunoelectronFlow CytometryFrozen SectionsImmunohistochemistryThe neutrophilic granulocyte is ...
Understanding the complex series of events involved in cell-cell interactions during leukocyte transendothelial migration is a prerequisite for designing novel therapies to treat clinical conditions in which an inappropriate inflammatory response leads ...
Acute myocardial infarction (AMI) has two clinical characteristics: high missed diagnosis and dysfunction of leukocytes. Transcriptional RNA on leukocytes is closely related to the course evolution of AMI patients. We hypothesized that transcriptional RN
through interendothelial junctions. The permeability of the endothelial barrier is an exquisitely regulated process in the resting state and in response to extracellular stimuli and mediators. The migratory properties of leukocytes or WBCs (white blo...
With an organ transplant, hematopoietic donor cells are transferred to the recipient. To study the relevance of the resulting microchimerism for allograft acceptance, we analyzed a rat model of cyclosporine-induced tolerance for strongly incompatible heart allografts. Using a monoclonal antibody that dete...
Granulocyte-colony stimulating factor (G-CSF) treatment of PMN enhances, and LPS inhibits, IL-8R mRNA expression. Similarly, 125I-IL-8 ligand binding to PMN is increased by G-CSF and decreased by LPS treatment. The stimulatory effect of G-CSF on IL-8R expression is transcriptional as it...
In addition, an other group has described N-cadherin to be involved in the transmigration process [40]. In conclusion, it seems that in the case of tumor cells, there is not such a clear difference between the receptors used for rolling, adhesion and diapedesis as it is for leukocytes. ...
It is yet unclear as to whether elevated levels of expression of IFN-inducible genes can be attributed to a response to the documented bacterial infection itself,13 or an undiagnosed or preceding viral infection. Thus, transcriptional signatures of host response to influenza infection and bacterial ...
CD14 binds to LPS but lacks an intracellular component and is, thus, incapable of signaling. Myeloid differentiation (MD)-2 is a protein necessary for LPS recognition by TLR4. MD-2 binds on TLR4 in the endoplas- mic reticulum/cis-Golgi and then the TLR4-MD-2 complex moves to the cell ...