Leukocyte adhesion deficiency type I (LAD-I) is an autosomal recessive disease characterized by impaired leukocyte diapedesis to sites of infection. The disorder is caused by mutations in the ITGB2 (integrin beta-2) gene. Herein, we report the first series of Algerian patients with LAD-I. In...
Leukocyte Adhesion Deficiency Type 1 LeukocyteadhesionAdhesionThe process whereby platelets adhere to something other than platelets, e.g., collagen; basement membrane; microfibrils; or other 'foreign' surfaces.Coagulation Studiesdeficiencytype 1Type 1Spinal Muscular Atrophy(LAD1) is an inherited condition...
Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. View Media Gallery This 3-year-old girl had leukocyte adhesion ...
Leukocyte adhesion deficiency type 1 (LAD-1) is an autosomal recessive disorder caused by mutations in the gene encoding CD18 or β2 integrin. The β2integrins are heterodimers, and CD18, which is required for normal expression, noncovalently binds to three individual α chains (CD11a, CD11b...
必应词典为您提供Leukocyte-Adhesion-Deficiency的释义,网络释义: 白血球黏着不足;白血球粘着缺乏症;白血球黏著不足;
The diminished expression of β2 integrins in patients with mutations in the ITGB2 (CD18) gene (leukocyte adhesion deficiency‐Type 1; LAD1) results in few or no neutrophils in peripheral tissues. In the periodontium, neutrophil paucity is associated with up‐regulation of IL‐23 and IL‐17...
2) bovine leukocyte adhesion deficiency 牛白细胞粘附缺陷病 1. In order to know the carrier and occurrence of bovine leukocyte adhesion deficiency (BLAD) among cows age from one to six years old in China, 1 000 cows were investigated by means of amplifying a CD18 gene fragment via reverse...
Medical Encyclopedia Wikipedia Related to leukocyte:polymorphonuclear leukocyte,Leukocyte count leu·ko·cyte alsoleu·co·cyte(lo͞o′kə-sīt′) n. Seewhite blood cell. leu′ko·cyt′ic(-sĭt′ĭk)adj. leu′ko·cy′toid′adj.
Leukocyte adhesion deficiency (LAD) I is a disorder caused due to mutations in a gene (ITGB2) located on chromosome 21 and encodes the β2 subunit of the leukocyte integrin molecules. This leads to defects in the adhesion of leukocytes on endothelial cells which further leads to recurrent micr...
白细胞粘附分子缺陷病5) bovine leukocyte adhesion deficiency 牛白细胞黏附缺陷症 1. A method for detecting bovine leukocyte adhesion deficiency in Hol-stein calves using polymerase chain reaction-single strand conforma-tion polymorphism analysis; 利用单链构象多态性检测牛白细胞黏附缺陷症方法的建立6...