Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency. The clinical picture is characterized by marked leukocytosis and localized bacterial infections that are difficult to detect until they have progressed to an extensive level secondar
Pathophysiology Integrins are important for: LeukocyteadhesionAdhesionThe process whereby platelets adhere to something other than platelets, e.g., collagen; basement membrane; microfibrils; or other ‘foreign’ surfaces.Coagulation Studiesto endothelial cells during migration ...
Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-CAM) deficiency. The leukocyte adhesion molecules CD11a/CD18, CD11b/CD18, and CD11c/CD18 (Leu-CAM) are members of the integrin receptor family and mediate cr...
Leukocyte adhesion deficiency (LAD) is a human disease associated with recurrent bacterial infections. The defect is in CD18, or β2 integrin, and results in the inability of neutrophils to be recruited from the blood to the site of infection. Chemokine and Chemokine Receptor Families Chemokines ...
Leukocyte Adhesion Molecules Deficiency: Its Structural Basis, Pathophysiology and Implications for Modulating the Inflammatory Response Understanding the molecular basis of a rare inherited disease, Leu-CAM deficiency in humans, has underscored the importance of the cellular component of inflammation and unra...
Differential Regulation of CD4+ T Cell Adhesion to Cerebral Microvascular Endothelium by the β-Chemokines CCL2 and CCL3 In Multiple sclerosis (MS), circulating lymphocytes cross the blood–brain barrier (BBB) and accumulate at sites of antigenic challenge. This process depen... K Liu,K Dorovini...
Integrin outside-in signalling occurs following the binding of leukocyte integrins to their counter-receptors on the endothelium and results in cytoskeletal rearrangements, strengthening of adhesion, cell spreading and migration. Epithelial–mesenchymal transition A process in which normally stationary epithelia...
iNOS−/− Deficiency Decreased Caspase-3 Activity and TUNEL Staining in Liver I/R Injury NO has been associated to adhesion-related apoptosis.39 MMPs may not only facilitate leukocyte migration, but they may also lead to detachment of liver cells resulting in apoptosis. Activation of caspase-...
Dissecting tumour pathophysiology using intravital microscopy Nat Rev Cancer, 2 (2002), pp. 266-276 CrossrefView in ScopusGoogle Scholar Kaburagi et al., 2002 Y. Kaburagi, M. Hasegawa, T. Nagaoka, et al. The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-sel...
junctional adhesion molecule A; LTB4: leukotriene B4; MCP-1: monocyte chemoattractant protein 1; MET: macrophage extracellular trap; MIF: macrophage migration inhibitory factor; MIP-1β: macrophage inflammatory protein 1β; MMP: matrix metalloproteinase; MPO: myeloperoxidase; MV: microvesicles; NET: ne...