Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU Stem cells are proposed to segregate chromosomes asymmetrically during self-renewing divisions so that older ('immortal') DNA strands are retained in daugh... MJ Kiel,S He,R Ashkenazi,... - 《Nature》 被引量: ...
At 5, 15, 30, and 60 min after injection, normal abdominal organs and xenotransplanted HeLa cells were sampled, and the uptake of each ligand was determined. Metabolic analyses of these compounds in the plasma were also performed. Accumulation of the d-isomers of (11)C-MET, (11)C-CMT,...
also reported recently that elevated cytosolic Ca2+ induces a mitochondrial shape transition in HeLa and MEF cells are dependent on MIRO1 but not DRP1 (Nemani et al. 2018), suggesting Ca2+-MIRO-1 plays a vital role in regulating mitochondrial morphology under diverse stresses and wounding. More...
After a small set of optimized leads or a lead candidate are identified, compounds can be evaluated in more physiologically relevant tier 2 cellular assays. These cellular models include human airway epithelial cells, normal human bronchial epithelial cells or pneumocytes derived from induced pluripotent...
Nup153 directs proteins involved in membrane remodeling to the nuclear envelope. As cells exit mitosis, Nup153 is recruited to the chromosomal surface, where nuclear pores are formed anew in a complicated process still under much experimental scrutiny. In addition, Nup153 is targeted for protease ...
abortus. In vitro systems using mammalian cells lines such as HeLa and macrophage-related were used along with the mouse model and host animal models. Results obtained at NADC and in other Brucellosis research laboratories, using survival in mammalian cell lines and the mouse model to access ...
Modeling the HSR in mammals benefited from ample experimental data that characterized the dynamics of HSF-HSE binding and the concentrations of the HSP-HSF complex, phosphorylated HSF1, HSP and HSP mRNA, and more. Heat shock experiments—mostly in HeLa cells—explored a range of stress temperature...
cells Review Lessons from the Endoplasmic Reticulum Ca2+ Transporters—A Cancer Connection Xingjian Zhai 1, Andra Mihaela Sterea 2 and Yassine El Hiani 1,* 1 Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada; xn980835@dal.ca 2 ...