SummaryLeishmania are unicellular eukaryotes that have many markedly original molecular features compared with other uni- or multicellular eukaryotes like yeasts or mammals. Genome plasticity in this parasite has been the subject of many publications, and has been associated with drug resistance or ...
The ABCA subfamily is absent in the yeast genome and was thought to be restricted to multicellular organisms (Broccardo et al., 1999). The presence of these transporters in the unicellular parasite Leishmania is interesting. ABCA1 appears to be involved in the control of membrane lipid ...
Is the fungus causing ringworm unicellular or multicellular? What infectious disease is caused by a protozoan? Do antibiotics work on leishmaniasis? What disease is caused by the amoeba? What microorganism causes schistosomiasis? What is amoeba infection? Is toxoplasmosis caused by a bacteria or virus...
Leishmaniahas anABCA1gene homologue (Table 16.1; F. Gamarro, Grenada, personal communication). The ABCA subfamily is absent in the yeast genome and was thought to be restricted to multicellular organisms (Broccardoet al., 1999). The presence of these transporters in the unicellular parasiteLeishm...
plays crucial roles in a multitude of physiological processes starting from embryogenesis to maintenance of the immune system. Initially believed to be the prerogative of multicellular organisms to use PCD for maintaining cellular homeostasis, it was later found to be prevalent in unicellular organisms ...
brucei and Leishmania.10–15 One of the proposed functions of a PCD pathway in unicellular organisms is to control the cell population by (i) selecting for the fitter cells within the population, (ii) optimally regulating the cell number to adapt to the environmental constraints and (iii) ...
Few natural antisense (as) RNAs have been reported as yet in the unicellular protozoan Leishmania. Here, we describe that Leishmania produces natural asRNAs complementary to all ribosomal RNA (rRNA) species. Interestingly, we show that drug-induced apopt
protein serine/threonine kinases and protein tyrosine kinases. The former are ubiquitous in eukaryotes. The latter are present in all metazoa for which the genome sequence is available, but relatively few examples have been found in unicellular eukaryotes [17,18]. However, protein tyrosine phosphoryla...
7), whereas centrin was uniformly required for centriole/basal body duplication and cytokinesis in all cell types studied in both unicellular as well as multicellular organisms (1, 2, 4, 5, 8, 9, 10, 28). Several mechanisms can explain failed cell division. Basal body/centriole duplication...
Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani. Cell Death Differ 2004; 11: 924–936. 12. Getachew F, Gedamu L. Leishmania donovani mitochondrial iron superoxide dismutase A is released into the cytosol during miltefosine...