This parasite has a complex life cycle composed of two distinct stages, the promastigote form found in the female sand-fly vector and the amastigote form that replicates in the mammalian host (Teixeira et al., 2013) [1]. To survive, the parasite interacts with its host immune system at ...
How these intracellular parasite antigens become exposed to the host immune system is accounted for by periodic cytolysis of the parasites during natural infection. This event is notable with a small number of parasites, even as they grow in an infected culture. The cytolysis of these parasites...
organization[6]. Furthermore, they have been important tools for studying the interaction between the mammalian host immune system and pathogens, since macrophages are their sole host target cell. TheLeishmaniagenome size is ∼35 Mb and chromosome sizes range from 0.3 to 2.8 Mb[7,8]. The...
The clinical presentation of visceral leishmaniasis depends strictly on the immunocompetency of the host and ranges from asymptomatic to severe forms. Conditions of depression of the immune system, such as HIV infection or immunosuppressive treatments, impair the capability of the immune response to ...
They function as host-cells to the parasite, they present parasite antigens to the immune system... J Mauël - 《Journal of Leukocyte Biology》 被引量: 100发表: 1990年 Leishmania–host interactions: what has imaging taught us? SummaryLeishmania parasites are well adapted to initiate infection...
2.1. Leishmanine Trypanosomatids Are Unicellular Organisms and Excellent Models to Explain Microbial Virulence Over time, Leishmania parasites have developed a number of highly effective strategies to overcome specific protective mechanisms by modulating the physiological responses of different host immune syst...
In addition, there is a growing global effort towards developing a potent multispecies Leishmania vaccine [24], and this will largely depend on our ability to fully understand the complex interaction between Leishmania and its mammalian host’s immune system. 2. Immunity to Leishmaniasis The ...
Immunity against Leishmaniasis: host resistance, immunotherapy and vaccinesISSN: 1756-3305 (Online) In this topical collection (19 articles) Research Efficacy of intranasal LaAg vaccine against Leishmania amazonensis infection in partially resistant C57Bl/6 mice Juliana Elena Silveira Pratti, Tadeu ...
Wenzel, U. A., Bank, E., Florian, C., Forster, S., Zimara, N., Steinacker, J., Klinger, M., Reiling, N., Ritter, U., and van Zandbergen, G. (2012) Leish- mania major parasite stage-dependent host cell invasion and immune evasion. FASEB J. 26, 29 -39...
The clinical presentation of visceral leishmaniasis depends strictly on the immunocompetency of the host and ranges from asymptomatic to severe forms. Conditions of depression of the immune system, such as HIV infection or immunosuppressive treatments, impair the capability of the immune response to ...