In patients with a guideline indication for statin therapy, those with chart‐documented LDL‐C testing in the prior 2 years had lower core laboratory LDL‐C levels at the time of enrollment than those without (median 9...
For those over 60, the drop has been from 232 to 204 (men) and 263 to 223 (women). Over the last 15 years the number of adult Americans using statins has risen from 3% to 9%.What have not gone down are levels of triglycerides. High triglycerides levels are linked to a higher risk...
The causal relation between elevated levels of LDL-C and cardiovascular disease has been largely established by experimental and clinical studies. Thus, the reduction of LDL-C levels is a major target for the prevention of cardiovascular disease. In the last decades, statins have been used as the...
Doctors will look at the total number, as well as the individual levels of LDLs and HDLs. A high individual count of HDLs is usually a good thing; they tend to hover around 50 for men and 60 for women. People average a 3-to-1 ratio of LDLs to HDLs. Regardless of...
that high concentrations of HDL (over 60 mg/dl) have protective value against cardiovascular diseases (such as ischemic stroke and myocardial infarction). Low concentrations of HDL (below 40 mg/dl for men, below 50 mg/dl for women) are a positive risk factor for these atherosclerotic diseases...
In HeFH patients, plasma LDL-C levels range from 5 to 13 mmol/L (from 190 to 500 mg/dL), and coronary heart disease typically occurs before 55 years in men and before 60 years in women [12]. In the HoFH population, plasma LDL-C levels are commonly above 13 mmol/L (500 mg/dL)...
We tested for association between the APOE polymorphism and LDL-C concentration using the model 1 and model 2 adjustment strategies. As a previous study of this population noted the APOE-sex interaction on circulating lipid levels (36), all analyses incorporated such interaction. The frequencies of...
cant improvement over the past two decades, the mean LDL-C levels in heFH French patients has remained stable since 2005. We also show that most heFH patients are not achieving their recommended LDL-C goals: this highlights the need for improved treatment and for new therapeutics in this ...
In PROSPER, women, but not men, with the A allele had higher LDL-C levels than those who did not. Additionally, following randomization to the pravastatin arm of the study (40 mg/day), women homozygous for the A allele displayed greater reduction in LDL-C than those with the G allele....
Moreover, whereas baseline levels of LpPLA2 mass in FH patients were at the upper limit of the normal range, apheresis dramatically reduced (up to 3-fold) LpPLA2 (Table 1); this finding is consistent with marked decrease in LDL, the major transport particle for this potentially ...