英文名称: Lymphocytic choriomeningitis virus (LCMV) (strain WE) GPC Protein (His & Myc) 英文同义词: Lymphocytic choriomeningitis virus (LCMV) (strain WE) GPC Protein (His & Myc) CAS号: 分子式: 分子量: 0 EINECS号: Mol文件: Mol File LYMPHOCYTIC CHORIOMENINGITIS VIRUS (LCMV) (STRAIN WE...
Here we demonstrate that although CD4+ and CD8+ T cells can produce elevated levels of cytokines in IL-10/ mice early after infection compared with WT mice, IL-10/ mice cannot clear an infection with the quicker replicating LCMV strain Docile, eventually resulting in T-cell exhaustion. These...
WT and Trem2 −/− mice were infected with LCMV strain WE. (A–C) Viral loads from serum (A), liver (B) and spleen (C) were quantified by immunological focus assay (n = 4–5 mice per group, representative of two independent experiments (B,C), data pooled from two ...
We pseudotyped non-primate feline immunodeficiency virus (FIV) vectors using LCMV derived glycoproteins with high or low affinity to α-DG and evaluated their properties in vitro and in vivo. Methods We pseudotyped FIV with the LCMV WE54 strain envelope glycoprotein and also engineered a point ...
Subsequently, we demonstrated that the QPCR assay can detect LCMV in tissues of CD40L -/- mice during a low grade chronic infection with LCMV armstrong. Finally, we improved the assay further such that it was approximately 1000-fold more sensitive than plaque assay for detection of the presence...
In order to assess the effect of PD-1/PD-L1 interaction on TCR signaling in vivo, we performed PD-L1 blockade3in mice that had been chronically infected for 3 weeks. Three hours after administration of the blocking antibody, various tissues were harvested and P14 cells were analyzed (Fig.6a...
The infection of SphK2-deficient (SphK2/) mice with LCMV Cl 13 resulted in kidney disease and ultimately mortality, which was not observed with acute infection by the Armstrong strain of LCMV. Following infection, SphK2/ mice were shown to have increased LCMV-specific CD4+ and CD8+ T cell...
We provide an explanation of the LCMV infection models, highlighting the importance of selecting an appropriate route and viral strain. We also describe how to quantify virus-specific immune responses, followed by an explanation of useful transgenic systems. Specifically, our article will focus on ...
LCMV-mediated hepatitis in rhesus macaques: WE but not ARM strain activates hepatocytes and induces liver regenerationdoi:10.1007/s00705-004-0385-9Igor LukashevichJuan RodasIlia TikhonovMaria Salvato
We pseudotyped FIV with the LCMV WE54 strain envelope glycoprotein and also engineered a point mutation in the WE54 envelope glycoprotein (L260F) to diminish α-DG affinity and direct binding to alternate receptors. We hypothesized that this change would alter in vivo tissue tropism and enhance ...