It is tempting to speculate about the biological impact of such a narrow gp33 response. We know that infection of a monoclonal gp33 P14 mouse with high titer virus stock results in the selection of escape mutants [35,36]. We might predict that a similar event would happen if these mice ...
No significant effect in the endogenous GP33–41 LCMV-specific response after the transfer of 2×103 P14 CD8 T cells.Georgia, FousteriAmy, DaveAmy, JuedesTherese, JunttiBret, MorinLisa, TogherDonna, L. FarberMatthias, von Herrath
aCD45.1+P14-Nr4a1-GFP cells were adoptively transferred into naive CD45.1+mice 1 day prior to high-dose LCMV clone 13 infection. Twenty-one days post infection, the hosts received gp33–41-pulsed or unpulsed labeled targets together with a reference population. Three hours later the mice we...