Since metabolism significantly affects drug safety and efficacy,determining the metabolic profile of a drug is a critical part of drug development.The appl... F Li,F Jgonzalez,X Ma - 药学学报:英文版 被引量: 0发表: 2012年 LC–MS-Based Metabolomics in the Study of Drug-Induced Liver Injury...
Summary LC–MS-based metabolomics has a great potential in drug metabolism, identification of biomarkers of cause and/or effect, and revealing the novel mechanisms of drug toxicity. In the future, metabolomics integrating with other omics can serve as an effective tool for investigating the ...
Acetaminophen (APAP)-induced acute toxicity is a clinically important model for studying drug-induced liver injury. In order to discover potential biomarkers of APAP-induced toxicity, a LC-MS-based metabolomic study was conducted to investigate the differential response from wildtype and cyp2e1-null...
Recently, computational and mathematical models of trypanosome metabolism have been generated to assist in understanding the parasite metabolism with the aim of facilitating drug development. Optimisation of these models requires quantitative information, including metabolite concentrations and/or metabolic fluxes...
Lastly, we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies (pharmacometrics, drug and vaccine developments, machine learning/artificial intelligence, among others) to encapsulate in an all-inclusive approach to improve treatment ...
Based on these, we expect to provide a novel perspective for discovering additional potential biomarkers and exploring the possible mechanisms of acupuncture-NMT combination in the treatment of stroke by combining 16S rRNA gene sequence with LC-MS metabolomics. This study utilized MCAO/R rat models ...
In this study, a new identification method of chiral metabolomics for detecting a slight difference in the amount of chiral amino acids was developed to examine cognitive decline as a function of the detected difference. Additionally, a chiral tandem LC-MS/MS system was developed for the high-se...
Li F, Gonzalez FJ, Ma X (2012) LC-MS-based metabolomics in profiling of drug metabolism and bioactivation. Acta Pharmaceutica Sinica B 2:118-25.Li, F.; Gonzalez, F.J.; Ma, X. LC-MS-based metabolomics in profiling of drug metabolism and bioactivation. Acta Pharm. Sin. B 2012, 2, ...
as well as on methods based on minimum cleanup (quick, easy, cheap, effective, rugged, and safe; QuEChERS) and dilute and shoot. The second part of the review deals with the untargeted determination of mycotoxins by LC coupled with high-resolution MS, which includes also metabolomics techniques...
Metabolomics-based approaches are still receiving growing attention with regard to food authenticity testing. Such studies require enormous sample numbers with negligible experimental or analytical variations to obtain statistically reliable results. In this context, an extraction protocol in line with optimize...