Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-β1 requires the binding of αvintegrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by...
Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-β1 requires the binding of αvintegrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by...
Latent forms of TGF-beta: molecular structure and mechanisms of activation. Ciba Found Symp, 1991; 157:81-9.Miyazono, K, Heldin, C-H Latent forms of TGFβ: molecular structure and mechanisms of activation. In: Bock, GR, Marsh, J eds. (1991) Clinical Applications of TGFβ. Wiley, ...
Latent forms of TGF-beta: molecular structure and mechanisms of activation. K Miyazono and C-H. Heldin, " Latent Forms of TGF-β : molecular structure and mechanisms of activation ", Ciba Foundation Symposium 157, 81-92 (... K Miyazono,CH Heldin - 《Ciba Foundation Symposium》 被引量:...
proof enough of the interest in this field of growth factor research. As the mature 25 kD forms of the TGF-betas are required for them to exert their many, diverse biological effects, it was inevitable that an explanation of the structure and of the activation of the latent complexes be so...
Latent TGF-beta structure and activation Nature, 474 (2011), pp. 343-349 Google Scholar [28] I. Nunes, P.E. Gleizes, C.N. Metz, D.B. Rifkin Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming...
OSS altered oxidation of free thiols to form more high molecular weight protein complex(es) than SS, a potential mechanism of shear-dependent LTGF-β1 activation. Increasing viscosity in platelet releasates produced higher shear stress and higher LTGF-β1 activation. OSS-generated active TGF-β1...
Latent TGF-β structure and activation. to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-β binding proteins... M Shi,J Zhu,R Wang,... - 《Nature》 被引量: 715发表: 2011年 Bone abnormalities in latent...
Latent-TGF-β: An overview Transforming growth factor-beta (TGF-beta) plays multiple homeostatic roles in the regulation of inflammation, proliferation, differentiation and would hea... David A. Lawrence 被引量: 0发表: 2001年 Latent TGF-β structure and activation. Transforming growth factor (TGF...
Platelets are a major source of transforming growth factor-beta1 (TGF-beta1) in the circulation as they release latent growth factor in response to activation. We report here that human platelets, when stimulated with thrombin, activated a significant proportion of the latent TGF-beta released. ...