latency is a rare event that occurs when a provirus fails to effectively express its genome and is reversibly silenced after integration into the host cell genome. This latent state is exceptionally stable and is limited only by the lifespan of the infected cell and its progeny. Post-integratio...
34. In addition, NK cells treated with varying doses of cell-free HIV supernatant in the absence of CD4+T cells demonstrated no notable increase in levels of intracellular IFN-γ or degranulation
HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days--Implications for HIV Remis- sion. PLoS Pathog. 2015; 11(7):e1005000. doi: 10.1371/journal.ppat.1005000 PMID: 26133551Pinkevych, M. et al. HIV reactivation from latency after treatment interruption ...
latency is a rare event that occurs when a provirus fails to effectively express its genome and is reversibly silenced after integration into the host cell genome. This latent state is exceptionally stable and is limited only by the lifespan of the infected cell and its progeny. Post-integratio...
However, pre-integration la- tency is clinically less important and less relevant in HIV-1 eradication strategies. Therefore, the focus of this review is the post- integration latency that occurs when a provirus fails to transcribe its genome and is reversibly silenced after in- tegration into ...
Eradication of HIV-1 from an infected individual cannot be achieved by current drug regimens. Viral reservoirs established early during the infection remain unaffected by anti-retroviral therapy and are able to replenish systemic infection upon interrupt
For most people living with HIV (PLWH), treatment with effective antiretroviral therapy (ART) results in suppression of viremia below the limit of detectio
Thus, when integration occurs in repressed chromatin, the provirus is heavily repressed, which is probably correlated with DNA methylation. Where the density of DNA methylation is less, the provirus enters a state of unstable gene expression, manifesting as variation of expression from cell to ...
Conversely, when the nontumorigenic phorbol ester prostratin is combined with histone deacetylase inhibitors, potent synergistic activation of latent HIV-1 occurs involving nuclear expression of NF-κB.These recent findings highlight both the antagonistic and agonistic effects of the NF-κB signaling ...
when compared in vitro6, and based on experimental and mathematical models, cell-to-cell transmission is thought to contribute to 60% of total virus infection7. HIV dissemination occurs in lymphoid tissues where a high concentration of T cells is present. DCs are thought to seed HIV infection ...