This is due to a stable pool of latently infected cells that cannot be targeted by antiretroviral therapy. Consequently, understanding the properties of this reservoir is vital to curing HIV. Existing latency models do not always reflect latency . Therefore this thesis presents both and experiments ...
PURPOSE OF REVIEW: To provide an overview of the initial experiences with the use of latency-reversing agents (LRAs) in clinical trials in HIV and to discuss and contrast results arising from these studies. RECENT FINDINGS: Although the clinical administration of histone deacetylase inhibitors (HDAC...
Treatment of human immunodeficiency virus type 1 (HIV-1) infection during the clinical latency phase with drugs inhibiting reverse transcriptase (RT) reduces the HIV-1 RNA load and increases the CD4+ T-cell count. Typically, however, the virus evolves mutations in the RT gene that circumvent th...
Areas covered: We discuss latency reversal agents (LRAs), broadly neutralizing antibodies, immunomodulatory therapies, and studies aimed at inducing apoptosis. Expert opinion: The landscape of clinical trials for HIV cure and remission has evolved considerably over the past 10 years. Several novel ...
Breaking the Silence: Regulation of HIV Transcription and Latency on the Road to a Cure Antiretroviral therapy (ART) has brought the HIV/AIDS epidemic under control, but a curative strategy for viral eradication is still needed. The cessation ... NN Duggan,T Dragic,SK Chanda,... - Viruses ...
Epigenetic control of HIV-1 post integration latency: implications for therapy. Clin. Epigenet. 7, 1–12 (2015). Google Scholar Burgos, J., Ribera, E. & Falcó, V. Antiretroviral therapy in advanced HIV disease: which is the best regimen? AIDS Rev. 20, 3–13 (2018). PubMed Google...
Mtbavoids or tolerates it. The lack of antigen presentation affects a lymphocyte-mediated immune response, mainly a T-mediated one. Granuloma formation is designed to contain and eliminateMtb; this is used by the pathogen to remain in a state of latency while waiting to become able to colon...
Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs. Nat. Rev. Microbiol. 2009, 7, 798–812. [Google Scholar] [CrossRef] [PubMed] Duarte, R.; Salgado, M.; Sánchez-Ortega, I.; Arnan, M.; Canals, C.; Domingo-Domenech, E.; Fernández-de-Sevilla, ...
The plasma was assessed for anti-KSHV antibodies by ELISAs specific for the latency-associated nuclear antigen (LANA, or ORF73) and the lytic structural glycoprotein K8.1, using previously described methods [39]. KSHV DNA was detected in DNA extracted from whole blood samples with plasma ...
This review summarizes results from recent studies that shed light on viral and cellular mechanisms that contribute to latency and persistence of Kaposi sarcoma-associated herpesvirus (KSHV). We discuss the initial molecular events of latency establishment starting from entry of the viral genome into th...