Laminin-511 E8 fragments permit ES/iPS cells to be maintained in feeder-free culture, enable passaging of single cells, and provide adhesion.
Laminin-511 E8,通常简称为LN511-E8,是一种特定形式的层粘连蛋白,为细胞提供结构支持并促使细胞彼此粘附。LN511-E8可以应用于诱导多功能干细胞(iPSC)的培养,它提供了一个支持性的基质,使得iPSCs能够粘附在培养皿表面上并进行增殖。这种基质能够通过与细胞表面受体的相互作用,促进细胞的黏附和扩增。Laminin511-E8无...
Laminin-511在促进细胞生长方面比其他Laminin如Laminin-111更有效。层粘连蛋白511 E8由α5、β1和γ1链的羧基端组成。Laminin-511异源三聚体(α5β1γ1)是一种待鉴定的异构体,在体外是多种正常和肿瘤细胞系的强粘附物和亲迁移底物。既往研究表明,在晚期乳腺癌和其他肿瘤类型中,laminin-511有助于肿瘤扩散和转移。
特别是Laminin-521和Laminin-511是两种重要的亚型,它们在维持多能干细胞增殖和特异性分化方面具有潜能。 层粘连蛋白511 E8是一种截短的层粘连蛋白511,由α5、β1 和γ1 链的羧基端组成。Laminin-511 E8作为功能最小的形式,保留了与整合素结合的全部能力。LN511-E8为细胞提供结构支持并促使细胞彼此粘附。LN511-...
货号:Laminin 511 品牌:ACRO 产地:北京 是否进口:否 更新时间2025-01-21 产品详情 Human Laminin 511 Protein, premium grade 产品描述(Product Details) Laminin 511 E8 (LN511-E8) is a recombinant human protein that provides a defined surface for in vitro feeder-free culture of multiple ...
Introduction Laminin 511 (LM511), a component of the skin basement membrane (BM), is known to enhance the adhesion of some cell types and it has been reported to affect cell behavior. A recombinant fragment consisting of the integrin recognition site; E8 region of LM511 (511E8) has also ...
Co-cultivation of limbal melanocytes with limbal epithelial stem/progenitor cells on fibrin hydrogels pre-incubated with LN-511-E8 resulted in multilayered stratified epithelial constructs within ten days. By reproducing physiological cell–cell and cell–matrix interactions of the native niche environment...
Laminin 511 E8 (LN511-E8) is a recombinant human protein that provides a defined surface for in vitro feeder-free culture of multiple human pluripotent stem cells (PSCs). Being a truncated form of laminin 511, LN511-E8 serves as a functionally minimal form that retain the full capability ...
Laminin 511 (LA8-H5283) could maintain the stemness of iPSC. Immunofluorescent staining indicated that the iPSCs expressed high levels of pluripotency associated markers Sox2, TRA-1-60, SSEA4 and OCT4. ★与Integrin的亲和力验证 Human Laminin 511 E8 Protein, Fc Tag, premium grade (Cat. No.LA...
该系列分为iMatrix-511 基质胶,iMatrix-511 silk基质胶,iMatrix-511 MG基质胶三个版本。 制品说明 层粘连蛋白 511 可与细胞表面的整合素 α6β1 结合。本制品是对层粘连蛋白 511 的整合素结合位点(E8 片段)进行高纯度纯化的制品。 制品内容 Recombinant Human Laminin511-E8 Fragments 包装量 175 μg/tube (...