Our lab has considerable experience studying LAD-ligation induced acute- and chronic- M.I, in the context of mice , rats and pigs and have successfully translated biomaterial- based therapeutics from small to large animals. We have noticed that the same procedure to induce M.I results in ...
Aidonidis I, Metz J, Gerstheimer F, Trautner H, Herbst M, Brachmann J (1986) Electrophysiologic and immunocytochemical observations in a coronary artery ligation and intramural occlusion model of recent myocardial infarction. Circulation 74:II-252, 1053 Google Scholar Borchard F, Paessens R (19...
Male Sprague-Dawley (SD) rats underwent left anterior descending (LAD) artery ligation to establish the CHF model and were subsequently administrated with different doses of XBP or Qili Qiangxin (QLQX). Cardiac functions were assessed using M-mode echocardiography. Cardiac remodeling and myocardial ...
The association of depressed angiogenic factors with reduced capillary density in the Rhesus monkey model of myocardial ischemia. Male Rhesus monkeys 2-3 years old were subjected to myocardial ischemia by permanent ligation of left anterior descending (LAD) artery leading to the ... Wenjing,Zhang,Xi...
Conclusions:Retrobypass is an effective technique to achieve long term survival after acute LAD occlusion in a pig model. Proximal ligation of V. cordis magna is mandatory. Additional experiments will focus on structural and functional investigations....