Lactate dehydrogenase(LDH) catalyzes the interconversion of pyruvate and lactate. LDH is a tetrameric protein made from two different (heart and muscle) subunits. LDH5 (a.k.a. LDH-A or M4) is usually expressed in muscle tissue and has a lowKmfor pyruvate, while LDH1 (a.k.a. H4) is...
Lactate dehydrogenase(LDH) catalyzes the synthesis of lactate andpyruvatein a reversible reaction, and is commonly used as a biomarker of cell damage or death. Normal distribution ofLDHand itsisoenzymesin skeletal muscles of rats revealed that, in controls, LDH activity was found to be highest in...
Lactate dehydrogenase(LDH),a vital enzyme in anaerobic glycolysis,is closely associated with the survival of parasites.Previous studies of some parasites have shown that LDH exhibits unique physicochemical properties and molecular structures and may be an ideal potential target for diagnosis and drug ...
24. The NAD-dependent D-LDHs were found in some bacteria and belong to the D-isomer specific 2-hydroxyacid dehydrogenase superfamily; however, the exact biological functions remain elusive25,26,27. The FAD-dependent D
▾ 外部资源(未审查的) Glycine has been reported for use in the enzymatic determinationoflactateusing lactic dehydrogenase. scbt.kr scbt.kr Glycine 可用在利用乳酸脱氢酶的乳酸酶法测定中。 scbt.com scbt.com [...] the presence of hypoglycorrhachia and low cerebrospinal fluid (CSF)lactateconcentra...
(nadh dehydrogenase), leading to the accumulation and conversion of nadh and pyruvate into lactic acid and resulting in lactic acidosis in cancer cells, which promotes cancer progression. blocking the lactate/gpr81 pathway with metformin can effectively inhibit glycolysis and decrease lactate levels ...
Lactylation may lead to tumor immunosuppression and immune escape by inhibiting the function of various immune cells in the TME. HK-1 hexokinase-1; G6PD glucose-6-phosphate dehydrogenase; PKM pyruvate kinase; SDH succinate dehydrogenase; IDH isocitrate dehydrogenase; TCA cycle tricarboxylic acid cycle...
The injured mice were treated with lactate, 4-CIN (a monocarboxylate transporter 2 inhibitor that can obstruct lactate transport into cells), and OX (an inhibitor of lactate dehydrogenase that can inhibit lactate production) after SCI (Fig. 3A). We found that lactate treatment increased lactate ...
The lactate shuttle concept is based on the fact that cells that produce high amounts of lactate through glycolytic metabolism extrude this lactate to the extracellular matrix, after replenishing the NAD+ pool, from where it is taken up by other malignant oxidative cells that use this lactate as...
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