Use of ethnopharmacological knowledge is one attractive way to reduce empiricism and enhance the probability of success in new drug-finding efforts (Patwardhan, 2005, Cordell and Colvard, 2005). Any effort to identify pharmacological action entails the access to both robust bioassays and targeted ...
Poorly planned CPOE order sets can lead to undetected errors and waste. In our emergency department (ED), lactate dehydrogenase (LDH) was bundled into various blood work panels but had little clinical value.ObjectivesThis quality improvement initiative aimed to reduce unnecessary LDH testing in the ...
Protein-protein interaction between the GtfB and LuxS proteins ofS. mutansand bacteriocin of SD1 inL. paracaseiwas found to reduce the formation of biofilm and the density of microorganisms, as revealed in a simulation study76. Following comprehensive bioinformatics analysis and characterization, the ba...
48 In the absence of prospective randomized trials, a widely used protocol in patients with malignancy-associated thrombocytopenia who have comorbidities, but who typically require therapeutic-dose anticoagulation (eg, for the treatment of symptomatic venous thromboembolism), is to reduce therapeutic-dose ...
(MUFAs), as well as a decrease in polyunsaturated fatty acids (PUFAs). SFAs are less prone to lipid peroxidation, compared with PUFAs [23]. Additionally, SFAs reduce membrane fluidity, resulting in changes in death receptors, apoptotic stimuli, and metastasis in cancer cells [24]. Overall, ...
The energy required to run filtration systems can account for 70 percent of a filter’s total cost. Using energy-efficient filters with a low average pressure drop can help reduce this. To maintain the expected efficiency level, filters should be replaced when the pressure drop doubles the init...
DNA methylation can regulate glycolysis related enzymes, inhibit mitochondrial functions and glyconeogenesis-related enzymes, promote aerobic glycolysis, enable the rapid energy needs of tumor cells to be met and reduce ROS damage. The PPP, which produces NADPH for redox equilibrium and raw material ...
The initial development of SPF laboratory rodents and lagomorphs was driven by research needs to establish suitable models free of infectious disease to improve animal health and welfare, reduce experimental variables, and improve experimental reproducibility and replicability (Baker, 2003; Council, 2000;...
Protein aggregation in biotherapeutics can reduce their activity and effectiveness. It may also promote immune reactions responsible for severe adverse effects. The impact of plastic materials on protein destabilization is not totally understood. Here, w
What can reduce the NAD/NADH ratio? How does phosphorylation affect cell signaling? How does fermentation allow glycolysis to continue? Why is NADH oxidized by lactate dehydrogenase in anaerobic conditions? How is coenzyme A formed in glycolysis? Why does alcohol inhibit gluconeogenesis? Does pyruvate...