Here, we describe experimental details of the small-micelle-mediated human organ efficient clearing and labeling (SHANEL) pipeline, which can be applied for cellular mapping of intact human organs. We have successfully cleared multiple human organs, including kidney, pancreas, heart, lung, spleen ...
The images were processed by region of interest (ROI) method to acquire the counts of whole body and the tumor and the counts ratios of tumor to contralateral normal tissue or to tissues of other non-tumor bearing organs. The mice were killed after 24 h postinjection imaging and tissue ...
Cancer cells inevitably interact with neighboring host tissue-resident cells during the process of metastatic colonization, establishing a metastatic niche to fuel their survival, growth, and invasion. However, the underlying mechanisms in the metastatic
Spine is one of the major organs in human body. It consists of multiple vertebrae and inter-vertebral discs. As the locations and labels of vertebrae provide a vertical reference framework to different organs in the torso, they play an important role in various neurological, orthopaedic and ...
TTP and HUS are disorders that can cause small blood clots to form throughout the body and decrease blood flow to body organs such as the brain, heart, and kidneys. Your healthcare provider will stop treatment with VALTREX if you have signs or symptoms of TTP and HUS. • kidney failur...
Additionally, the presence of progenitor cells has been described in the human IVD [73, 74], and the possibility of influencing the proliferation and differentiation of human degenerated IVD cells in vitro was recently reported [16]. Previously, increased cell proliferation and cell migration in ...
Many biological processes are executed and regulated through the molecular interactions of proteins and nucleic acids. Proximity labeling (PL) is a technology for tagging the endogenous interaction partners of specific protein ‘baits’, via genetic fusi
(PBS injection as the control, Fig.4a). To monitor biodistribution of the azido-modified EVs, we collected the mouse samples of plasma, tumor tissue, and tissue from four major organs (heart, liver, lung and kidney). EVs in the plasma samples were directly analyzed by Melac-Chip, while ...
Processes and structures within the body that are normally hidden from the eye can be made visible through medical imaging. Scientists use imaging to investigate the complex functions of cells and organs and search for ways to better detect and treat diseases. In everyday medical practice, images...
organs or fluids; germinal cells including sperm and egg cells, seeds, pollen, or zygotes, embryos, chorionic or amniotic cells, or cells from any other germinating body; cells grown in vitro, from either long-term or short-term culture, and either normal, immortalized or transformed; inter-...