The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual’s body during their lifetime. Understanding the complexities of the proteome in the context...
The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual’s body during their lifetime. Understanding the complexities of the proteome in the context...
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Here we carried out complete autopsies on 44 patients who died with COVID-19, with extensive sampling of the central nervous system in 11 of these patients, to map and quantify the distribution, replication and cell-type specificity of SARS-CoV-2 across the human body, including the brain, ...
the intestinal mucosal immune system—the largest pool of immune cells in the human body7—ensures homeostasis by perpetual policing of the interface between the intestinal barrier and luminal contents. Disruption of intestinal immune function can lead to various pathologies, including persistent infections...
method for detection of radiolabelled organs, in particular organs in the human or animal bodyGUENTHER DREXLER DR-INGFRANZ PERZL DR RER NAT
(2) hCD147KI-NSG mice are marginally sensitive to SARS-CoV-2 infection compared to WT-NSG littermates characterized by increased viral copies by qRT-PCR and moderate body weight decline compared to baseline; (3) a significant increase in leukocytes in the lungs of hCD147KI-NSG mice, ...
10) [69]. Not all structures were able to quench the labelled FAM-ssDNA4. This was attributed to a number of factors such as the narrow pore size (approximately ca. 5.4 × 10.8 Å for ZnMOF3 and ZnMOF5), the dimensionality (ZnMOF4 and ZnMOF6 are layered materials for ...
Within the stromal compartment, we identified subtypes of myofibroblast, smooth muscle cells, pericyte, interstitial cells of Cajal, mesothelium and populations resembling stromal cells previously described in the colon5 (labelled as stromal 1–4) (Fig. 4d, Extended Data Fig. 2a). We further iden...
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