The advancement of technology in measuring stiffness of individual cells has resulted in powerful techniques capable of bridging the gap between mechanical properties and cellular functioning and structures. Pioneering research over two decades ago demonstrated the importance of mechanical properties in charact...
Osteoarthritis (OA) is characterized by the progressive deterioration of articular cartilage, involving complicated cell-matrix interactions. Systematic investigations of dynamic cellular and matrix changes during OA progression are lacking. In this study, we use label-free two-photon excited fluorescence (...
However, its application has been mostly restricted to thin preparations or small samples owing to the difficulty of labeling and observing deep structures in intact specimens. 3D imaging is particularly valuable when analyzing complex structures that are not contained within 2D planes, such as axonal...
Synovial fluid (SF), a proximal fluid which bathes the intrinsic joint structures, is an important reservoir of putative protein and peptide biomarkers whose abundance levels fluctuate in response to pathological changes due to disease [10]. In the current study, we performed MS-based proteomic ...
The classification was dependent on the sample data from which it was acquired. The data were collected under the Supervision of the Stroke Coordinator at the Metro-Rehab Hospital. The data was collected in three phases at each posture (flexion or extension) of the knee joint. The healthy and...
(5S)–2-oxo-3-[4-(3-oxomorpholin-4-yl) phenyl] 1, 3-oxazolidin-5-yl methyl) thiophene-2-carboxamide (Figure S1 (see Supporting Information)) is an oxazolidinone derivative anticoagulant that is increasingly being used to prevent blood coagulation following hip or complete knee replacement ...
articular cartilage;3D bioprinting;adipose tissue;allogenic hyaline cartilage;knee;osteoarthritis 1. Introduction Knee osteoarthritis (KOA) is the most common progressive disease-causing musculoskeletal disability for patients in the world [1]. Its pathogenesis includes detrimental alterations of the joint, ...