Label-Free Screening Small-Molecule Compound Libraries forProtein-Ligands Using a High-Throughput Optical ScanningMicroscopemicroarrayshigh-throughput... YY Fei,JP Landry,YS Sun,... - Conference on Imaging 被引量: 0发表: 2009年 A novel high-throughput scanning microscope for label-free detection of...
against a pump power that is coupled to the Er-DCF. A maximum power of up to 12.9 W was achieved at a PRR of 25 kHz under a pump power of 62.6 W. The output power was stable, with root-mean-square fluctuation of <1% when the average power was monitored for 30 ...
Using an oblique-incidence reflectivity difference (OI-RD) scanning microscope as a label-free detector, we performed a comparative study of the effectiveness of BSA and PVA as macromolecular scaffolds for anchoring small molecule compounds in terms of conjugation efficiency, surface immobilization ...
MedianThe sewing machine eye as a center, between the respective side sewing machine eyes, in the crosswiseLong transparent transparent film label 20 was applied to backIt is stuck by the adhesive compound. Transparent film labelPutting, to disconnect the side sewing machine eye and the median ...
However, CARS microscope could detect taurine in wet tissue block. This takes advantage of the higher spatial resolution and effective NRB removal of CARS in our setup. This underscores the strength of CARS microscopy for characterisation of small molecule compound in wet biological tissues. ...
Photographs were taken with an Olympus DP10 digital camera attachment with a C-mount adapter mounted on an Olympus BX40 compound microscope with 4×, 10×, 20× and 40× power objectives. Samples were scored as positive if there were ≥ 50% of cells with 1+ or greater staining intensity ...
By combining microscopy with Raman spectroscopy, Raman microscope scans over a sample and measures the Raman spectra of all pixels within the sample at the same time; therefore can provide the spatial distributions and chemical structures of multiple components of samples simultaneously at the ...
The prospect of COMBImage was demonstrated in the context of an ongoing DDD project, focused on the development of new multicompound therapies for glioblastoma multiforme (GBM); a highly aggressive and the most common primary brain tumor in adults. It exhibits extremely poor prognosis that has bee...
This system is equipped with a 532 nm diode laser, an air-cooled charge-coupled device (CCD) and a Leica DMLM microscope. The hyperspectral imaging data were acquired under the 50× objective with a step size of 2 μm for both the x and y directions. Each collected spectrum ranged ...
(ThorLabs, Ann Arbor, Michigan, USA) adjusted for this wavelength. The laser was coupled to the microscope by an optical fiber with a diameter of 50 μm and signal was collected by the Andor Newton DU970N-BV-353 CCD camera (Oxford Instruments, Abingdon, England) with 1600 × 200 ...